Variations in renal arteriolar diameter in deoxycorticosterone acetate-salt hypertensive rats. A microvascular cast study

Virchows Archiv. A, Pathological Anatomy and Histopathology
A TojoT Sugimoto

Abstract

The relation between hypertensive glomerular damage and arteriolar diameter was examined in a microvascular cast study in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. The blood pressure and urinary protein excretion increased progressively in the DOCA rats. In controls afferent arteriolar diameters increased during the course of the experiment, and efferent arteriolar diameters remained unchanged. In the DOCA rats, however, afferent arteriolar diameters did not change significantly, while efferent arteriolar diameters increased. Histological studies showed severe arteriolosclerosis and glomerulosclerosis in the DOCA rats. The results show that these arteriolar changes might contribute to the reduction of glomerular capillary pressure in the development of DOCA-salt hypertension. However, they are not sufficient to protect glomeruli from hypertensive damage.

References

Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·K KimuraT Sugimoto
Apr 1, 1989·Circulation Research·C F Sanchez-FerrerD R Harder
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Citations

Jan 1, 1991·Virchows Archiv. A, Pathological Anatomy and Histopathology·H Wehner, G Nelischer
Apr 21, 2005·Kidney International·Kensuke AsabaChristopher S Wilcox
Aug 21, 2013·Journal of Diabetes Research·Michio HayashiToshiro Fujita
Jul 9, 2011·Diabetes & Metabolism Journal·Mi Young LeeChoon Hee Chung
Oct 2, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nicole EndlichKarlhans Endlich
Jul 31, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Akira IshimitsuToshihiko Ishimitsu

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