Variations in response to trauma and hippocampal subfield changes.

Neurobiology of Stress
Charlotte PostelPierre Gagnepain

Abstract

Models of posttraumatic stress disorder (PTSD) suggest that the hippocampus is key to the persistence of traumatic memory. Yet very little is known about the precise changes that take place in this structure, nor their relation with PTSD symptoms. Previous studies have mostly used magnetic resonance imaging (MRI) at low resolutions, making it impossible to identify sensitive anatomical landmarks, or compared groups often unequally matched in terms of traumatic exposure. The present cross-sectional study included 92 individuals who had all been exposed to the terrorist attacks in Paris on November 13, 2015 (53 of whom subsequently developed PTSD) and 56 individuals who had not been exposed. Hippocampal subfield volumes were estimated using cross-validated automatic segmentation of high-resolution MRI images. Results revealed changes in CA1 and CA2-3/dentate gyrus (DG) volumes in individuals with PTSD, but not in resilient (i.e., exposed but without PTSD) individuals, after controlling for potential nuisance variables such as previous traumatic exposure and substance abuse. In line with current models of hippocampal subfield functions, CA1 changes were linked to the uncontrollable re-experiencing of intrusive memories, while CA2-...Continue Reading

References

Dec 1, 1972·Postgraduate Medicine·A T Beck, R W Beck
Apr 1, 1993·Archives of General Psychiatry·S M SouthwickD S Charney
Aug 9, 1996·Science·R M Sapolsky
Oct 1, 1996·Behaviour Research and Therapy·E B BlanchardJ Jones-Alexander
Apr 29, 1998·Journal of Anxiety Disorders·E B BlanchardA E Taylor
Oct 16, 2002·Nature Neuroscience·Mark W GilbertsonRoger K Pitman
Nov 20, 2002·Comprehensive Psychiatry·Caron ZlotnickMark Zimmerman
Jan 31, 2004·The European Journal of Neuroscience·Vivi M HeinePaul J Lucassen
Mar 3, 2004·Molecular Interventions·Rosanne M Thomas, Daniel A Peterson
Oct 16, 2004·Depression and Anxiety·Wei ZhangJonathan R T Davidson
Feb 18, 2010·Neuron·Valerie A CarrAnthony D Wagner
Mar 3, 2010·Archives of General Psychiatry·Zhen WangNorbert Schuff
Apr 2, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Wen HuWeiqi Zhang
Jul 27, 2010·Journal of Anxiety Disorders·Judith CukorJoann Difede
May 7, 2011·Current Opinion in Neurobiology·Ki Ann Goosens
Jul 27, 2011·Trends in Neurosciences·Michael A Yassa, Craig E L Stark
May 18, 2012·Frontiers in Cellular Neuroscience·Benjamin H Levy, Jeffrey G Tasker
Oct 11, 2012·Nature Reviews. Neuroscience·Roger K PitmanIsrael Liberzon
Nov 29, 2012·Nature Neuroscience·Mazen A KheirbekRené Hen
Jan 11, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Maura BoldriniJ John Mann
Jan 22, 2013·Frontiers in Psychology·Cyril R PernetGuillaume A Rousselet
Sep 23, 2014·Current Opinion in Neurobiology·Bradley R Miller, René Hen
Oct 14, 2014·Frontiers in Aging Neuroscience·Laura E M WisseMirjam I Geerlings
Dec 3, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Hagit CohenZeev Kaplan
May 6, 2015·NeuroImage·Juan Eugenio IglesiasUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jun 13, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Antoine Besnard, Amar Sahay
Jun 17, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bruce S McEwenJason D Gray
Aug 5, 2015·Biological Psychiatry·Aline DesmedtPier-Vincenzo Piazza
Sep 22, 2015·Psychological Trauma : Theory, Research, Practice and Policy·Mira BrancuJennifer J Runnals
Sep 26, 2015·Nature Neuroscience·Bruce S McEwenCarla Nasca
Oct 1, 2015·Psychiatry Research·Susanne G MuellerMichael W Weiner
Nov 26, 2015·Journal of Traumatic Stress·Christy A BlevinsJessica L Domino
Feb 3, 2016·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Martin H Teicher, Jacqueline A Samson
Feb 6, 2016·AJNR. American Journal of Neuroradiology·L E M WisseM I Geerlings

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