Variations in serotypes and susceptibility of adult non-invasive Streptococcus pneumoniae isolates between the periods before (May 2000-May 2001) and 10 years after (May 2010-May 2011) introduction of conjugate vaccines for child immunisation in Spain

International Journal of Antimicrobial Agents
A FenollPilar Coronel

Abstract

This study explored the serotype distribution and antibiotic susceptibility of adult non-invasive Streptococcus pneumoniae isolates received in the Spanish Reference Laboratory for Pneumococci immediately prior to introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) in June 2001 (May 2000-May 2001) and 10 years afterwards (May 2010-May 2011). Serotyping was performed by Quellung reaction and/or dot-blot assay, and minimum inhibitory concentrations (MICs) were determined by agar dilution. Clinical and Laboratory Standards Institute (CLSI) breakpoints were used for susceptibility interpretation. A total of 1274 isolates were identified (650 in the first period and 624 in the second period). PCV7 serotypes (as a group) showed a decrease (P<0.001) from 43.2% in the first period to 13.9% in the second period, with MIC(90) values (MIC for 90% of the organisms) of levofloxacin for the remaining PCV7 serotypes of 16 μg/mL. Inversely, non-PCV7 serotypes (as a group) increased from 56.8% to 86.1% (P<0.001), mainly due to increases in serotypes 19A (294.1% increase; P<0.001) and 15A (180.0% increase; P=0.005). Globally, non-susceptibility to penicillin decreased from 54.2% in the first period to 36.9% in the second period (P...Continue Reading

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Citations

Dec 10, 2013·Archivos de bronconeumología·Mercedes Arencibia JiménezPilar López García
Nov 28, 2012·Revista Clínica Espanõla·P Cardinal-FernándezG Rieppi
Dec 12, 2012·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·D Moreno-PérezUNKNOWN Comité Asesor de Vacunas de la Asociación Española de Pediatría, España
Oct 12, 2012·World Journal of Surgery·Drake G LebrunK A Kelly McQueen
Aug 8, 2017·Expert Review of Vaccines·Raul IsturizLuis Jodar
Oct 9, 2013·The Medical Journal of Australia·Janet E StrachanGeoffrey G Hogg
Nov 16, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·L GeorgalisM Garrido-Estepa
Apr 2, 2020·Enfermedades infecciosas y microbiología clínica·Jose Maria Marimon, Carmen Ardanuy

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