Variations in the alpha2A-adrenergic receptor gene and their functional effects

Clinical Pharmacology and Therapeutics
Daniel KurnikC Michael Stein

Abstract

The alpha2A-adrenergic receptor (ADRA2A) plays a central role in the regulation of systemic sympathetic activity and hence cardiovascular responses such as heart rate and blood pressure. The objectives of this study were to systematically search for variants in the ADRA2A gene, to define the gene's haplotype structure, and to examine potential functional effects of these variants. We examined 5957 base pairs of contiguous sequence of ADRA2A (promoter, exonic, and 3'-flanking region) using polymerase chain reaction to amplify the genomic target, followed by bidirectional sequencing, in 135 healthy subjects (85 white and 50 black subjects). Haplotypes were inferred by use of an expectation-maximization algorithm. Primary (plasma norepinephrine concentration) and secondary (resting heart rate and blood pressure) phenotypes were compared among subjects grouped by individual polymorphisms and haplotypes. We identified 41 variants, including 24 novel variants. On the basis of 9 optimally selected markers, 11 haplotypes in 5 haplotype groups were inferred, representing approximately 99% of the cohort. Two uncommon variants in complete linkage disequilibrium (G>C at -1903 and C>G at -1607, identified in 3 black subjects) were associate...Continue Reading

Citations

Jul 2, 2010·The Journal of Clinical Hypertension·Zhila TaherzadehEd VanBavel
Nov 26, 2010·European Archives of Psychiatry and Clinical Neuroscience·Verônica ContiniClaiton H D Bau
Feb 22, 2014·TheScientificWorldJournal·Samantha F HollidayPamela L Smithburger
Mar 26, 2013·Obesity·Ewa-Carin LångbergClaes-Göran Östenson
Oct 9, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Nadine SpielmannClaude Bouchard
Jun 11, 2015·Physiological Genomics·Utkarsh KohliDaniel Kurnik
Sep 25, 2010·Psychiatry Research·Caio Cesar Silva de CerqueiraClaiton Henrique Dotto Bau
Jan 13, 2020·Chemical Science·Xiangxiang ZengFeixiong Cheng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.