Variations in tissue resistivity and in the extension of activated neuron domains shape the voltage signal during spreading depression in the CA1 in vivo

The European Journal of Neuroscience
Julia MakarovaO Herreras

Abstract

Spreading depression (SD), a wave of neuron activity related to migraine and the ischaemic penumbra, features a moving shell of extracellular negative potential shift (V(o)) whose generators are poorly understood. We investigated its subcellular correlates in the hippocampal CA1 in vivo by localizing the neuron domains that generate transmembrane current (I(m)) using field analysis, and the local changes of tissue resistivity, a major determinant of extracellular current flow. A large increase of tissue resistivity occurred in times and dendritic strata displaying large V(o), albeit with different rates. Typically, SD is composed of basal and apical dendritic components. The apical SD lasts much longer, while it becomes gradually restricted to a narrow dendritic region. Strikingly, pyramidal cells displayed a strong surge of inward current only when SD affected a small dendritic region. However, when the V(o) signal covered most of the main neuron axis, only smaller surges of inward current developed at the outer dendritic rims of a wide null current zone. Computational reconstruction showed that this effect was due to strong spatial cancellation of the inward and outward currents in SD-activated isopotential and shunted region...Continue Reading

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Citations

Jan 23, 2010·Journal of Computational Neuroscience·Valeri A MakarovOscar Herreras
Sep 22, 2009·Neural Computation·Daniel K Wójcik, Szymon Leski
Nov 2, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeremy J TheriotK C Brennan
May 27, 2014·Nature Reviews. Neuroscience·Daniela Pietrobon, Michael A Moskowitz
Nov 4, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Martin LauritzenAnthony John Strong
Jan 10, 2018·Frontiers in Cellular Neuroscience·Azat NasretdinovRoustem Khazipov
Jun 26, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Oscar Herreras, Julia Makarova
Jun 10, 2018·Scientific Reports·Andrew J WhalenSteven J Schiff
Nov 23, 2019·Epilepsia·Andrey ZakharovRoustem Khazipov

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