Variations of Epstein-Barr virus nuclear antigen 1 gene in gastric carcinomas and nasopharyngeal carcinomas from Northern China

Virus Research
Yun WangBing Luo

Abstract

The Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1), the only viral protein consistently expressed in all EBV-associated tumors, is classified into five distinct subtypes: P-ala, P-thr, V-leu, V-val and V-pro based on the signature changes at amino acid residue 487. By now, whether the EBNA1 subtypes preferentially associate with particular malignancies or represent geographical polymorphism remains controversial. In China, most studies of the EBNA1 variations focused on nasopharyngeal carcinoma (NPC) in endemic area, among which some suggested the V-val subtype is preferentially associated with NPC. To characterize the variations of EBNA1 in NPC non-endemic area in China and to explore the association of EBNA1 variations with EBV-associated gastric carcinoma (EBVaGC) and NPC, the C-terminal sequences of EBNA1 were analyzed for 41 EBVaGC, 41 NPC biopsies and 55 throat washing (TW) samples from healthy donors in Northern China. Three major patterns of the EBNA1 variations, V-val, P-thrV and V-leuV, were observed, and V-val was the most common subtype in all the three groups, followed by P-thrV and V-leuV. The distribution of the EBNA1 subtypes among EBVaGC, NPC and healthy donors was not significantly different (P>0.05). In a...Continue Reading

References

Apr 10, 1997·International Journal of Cancer. Journal International Du Cancer·K QiuK Aozasa
Jul 3, 1997·International Journal of Cancer. Journal International Du Cancer·J SidagisY Eizuru
May 14, 1998·International Journal of Cancer. Journal International Du Cancer·S T CheungD P Huang
Jan 11, 2000·Journal of Virology·R S MidgleyS P Lee
Mar 14, 2000·Reviews in Medical Virology·E R Leight, B Sugden
Nov 25, 2000·Molecular Pathology : MP·G Niedobitek
Jan 24, 2002·AIDS Research and Human Retroviruses·Lucia FassoneLuigi Maria Larocca
Feb 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matthew P Thompson, Razelle Kurzrock
Mar 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hye Seung LeeWoo Ho Kim
Jan 11, 2005·Proceedings of the National Academy of Sciences of the United States of America·Myung-Soo KangElliott Kieff
May 16, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Elisabeth Puchhammer-Stöckl, Irene Görzer
Feb 8, 2008·Journal of Virology·Myung-Soo KangElliott Kieff
Apr 19, 2008·The Journal of Infectious Diseases·Melissa J BellScott R Burrows
Jan 24, 2009·International Journal of Cancer. Journal International Du Cancer·Georg W Bornkamm
Apr 2, 2009·Journal of Gastroenterology and Hepatology·Ju-Han LeeYoung-Sik Kim

❮ Previous
Next ❯

Citations

Aug 19, 2011·FEBS Letters·Abhik Saha, Erle S Robertson
Sep 10, 2010·Journal of Medical Virology·Mario Alejandro LorenzettiMaría Victoria Preciado
Sep 10, 2014·Naunyn-Schmiedeberg's Archives of Pharmacology·Shuvomoy BanerjeeErle S Robertson
Jul 20, 2016·Journal of Medical Virology·Marco NevesHugo Sousa
Jan 1, 2012·Pathogens·Stelios Tzellos, Paul J Farrell
Jul 14, 2017·Journal of Virology·Julianna S DeakynePaul M Lieberman
Mar 7, 2012·Journal of Clinical Gastroenterology·Jian-Ning ChenChun-Kui Shao
Mar 13, 2014·Journal of Medical Virology·Ying YangBing Luo
Jan 13, 2017·Oncotarget·Jayaraju DheekolluPaul M Lieberman
Nov 19, 2019·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Mohammad Hadi Karbalaie NiyaAlireza Tabibzadeh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.