PMID: 9430356Jan 1, 1997Paper

Variations of hepatitis B virus core gene sequence in Western patients with chronic hepatitis B virus infection

Journal of Viral Hepatitis
A H GrayJ Y Lau

Abstract

Heterogeneity of the hepatitis B virus (HBV) core gene has been reported to be associated with the presence of active liver disease in Japanese patients with chronic HBV infection. This study evaluated the significance of HBV core gene heterogeneity in Western patients with chronic HBV infection. The hepatitis B virus precore/core gene from 45 patients (inactive:active liver disease ratio 16:29) was amplified from serum by polymerase chain reaction (PCR). Gel electrophoresis was employed to detect large deletions. The PCR amplicons from 13 patients (all HBV serotype adw but with a different spectrum of liver disease) were cloned and sequenced. Hepatitis B surface antigen (HBsAg) serotypes were tested by enzyme immunoassay (EIA) and hepatic expression of HBV antigens was assessed by immunohistochemistry. The HBV core gene was amplified from the serum of all 45 patients. Three patients had mixed infection with both precore mutant and wild-type HBV and all three had active liver disease. No patient had a large deletion of the HBV core gene. Hepatitis B virus core gene sequence variations were more common in the midcore region and there was no difference in the number of silent and missense substitutions between those with inactive...Continue Reading

Citations

Aug 2, 2003·Gastroenterology·Chi-Jen ChuAnna S F Lok
Aug 27, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chi-Jen ChuUNKNOWN U.S. HBV Epidemiology Study Group
Jun 24, 2005·IEEE Transactions on Systems, Man, and Cybernetics. Part B, Cybernetics : a Publication of the IEEE Systems, Man, and Cybernetics Society·Georg SchneiderEdgar Körner
Feb 19, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·S B RutkoveJ E Larrabee
Oct 27, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Masataka TsugeKatsutoshi Yoshizato
Sep 10, 1999·Reviews in Medical Virology·S L NguiC G Teo

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