Variations of pituitary function over time after brain injuries: the lesson from a prospective study

Pituitary
Giulio GiordanoEzio Ghigo

Abstract

Traumatic Brain Injury (TBI) and Subarachnoid Haemorrhage (SAH) are conditions at high risk to develop hypopituitarism as pointed out by many papers in scientific literature. But most of the papers were referred to retrospective evaluations, not considering the possible evolution of the pituitary function over time. Aim of our studies was to clarify whether pituitary deficiencies and normal pituitary function recorded at short term follow-up (3 months), would improve or worsen, respectively, at long term (12 months after the brain injury). In a multicenter study protocol, in patients who suffered TBI (n = 70; 50 Males, 20 Females; age 39.31 +/- 2.4 years; BMI 23.8 +/- 0.4 kg/m(2)) or SAH (n = 32; 12M, 20F; age: 51.9 +/- 2.2 year; BMI: 24.7 +/- 0.6 kg/m(2)) we tested 3 and 12 months after the pathological events the pituitary function. In TBI patients, the 3 month evaluation had shown some degree of hypopituitarism in 32.8% and the 12 months retesting demonstrated some degree of hypopituitarism in 22.7%. Total hypopituitarism was always confirmed at 12 months while Multiple and Isolated deficits recorded at 3 months was confirmed in nearly 25% only of the patients. On the other hand, in 5.5% of TBI with normal pituitary function...Continue Reading

References

Jan 10, 1981·British Medical Journal·B Jennett, R MacMillan
Jul 22, 1998·Lancet·S W LambertsA J van der Lely
Nov 5, 1998·Journal of Endocrinological Investigation·G AimarettiE Ghigo
Feb 15, 2000·The Journal of Head Trauma Rehabilitation·D J ThurmanJ E Sniezek
Apr 19, 2000·The Journal of Clinical Endocrinology and Metabolism·S BenvengaF Trimarchi
Oct 14, 2000·Ryōikibetsu shōkōgun shirīzu·T Mitsuma, Y Hirooka
Jun 9, 2001·The Journal of Clinical Endocrinology and Metabolism·S A LiebermanR J Urban
Feb 12, 2002·The Journal of Clinical Endocrinology and Metabolism·Mark L HartmanUNKNOWN U.S. HypoCCS Study Group
Jan 7, 2004·Acta Neurologica Scandinavica·L BrandtP Reinstrup
Apr 24, 2004·Clinical Endocrinology·Amar AghaChristopher J Thompson
May 12, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·G AimarettiUNKNOWN Italian Society of Endocrinology
Jul 16, 2004·Journal of Neurotrauma·Marta BondanelliEttore C I degli Uberti
Oct 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Amar AghaChristopher J Thompson
Oct 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Ilonka Kreitschmann-AndermahrJoachim M Gilsbach
Jan 8, 2005·Journal of Endocrinological Investigation·F F CasanuevaUNKNOWN Athens TBI and Hypopituitarism Study Group
Sep 8, 2005·The Journal of Clinical Endocrinology and Metabolism·Gianluca AimarettiEzio Ghigo
May 1, 1996·Trends in Endocrinology and Metabolism : TEM·X Xu, W E Sonntag

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Citations

Aug 6, 2010·Journal of Neurotrauma·Rebecca Jane MoonJustin Huw Davies
Sep 14, 2013·Endocrine·Erick Richmond, Alan D Rogol
Jan 18, 2007·European Journal of Pediatrics·Preamrudee Poomthavorn, Margaret Zacharin
Aug 5, 2015·Journal of Clinical Medicine·Robert A Scranton, David S Baskin
Nov 26, 2010·The Psychiatric Clinics of North America·Jaime M Levine, Steven R Flanagan
Dec 23, 2008·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Dorothee WachterDieter-Karsten Böker
Jan 16, 2007·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Gergely SárközyMatthias Keller
Jun 10, 2014·Brain Injury : [BI]·Sabrina NourollahiMarcela Lippert-Grüner
Oct 1, 2008·Neurosurgery·Kyle A WeantMatthew Ewend
Jan 31, 2014·Journal of Neurology·Amanda Jayne BarughGillian Elizabeth Mead
Apr 8, 2009·The Journal of Clinical Endocrinology and Metabolism·Wiebke Arlt
Jul 30, 2011·Neurocritical Care·P Vespa, UNKNOWN Participants in the International Multi-Disciplinary Consensus Conference on the Critical Care Management of Subarachnoid He
Aug 3, 2011·Neurocritical Care·Paul Vespa, UNKNOWN Participants in the International Multi-Disciplinary Consensus Conference on the Critical Care Management of Subarachnoid He
May 4, 2010·Journal of Pediatric Endocrinology & Metabolism : JPEM·Nina S MaMark Borchert
Mar 31, 2019·Pituitary·Aydin SavKalman Kovacs
Jun 20, 2007·Brain Injury : [BI]·Fateme SalehiMichael Cusimano

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