PMID: 9171100Jun 15, 1997Paper

Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins

Nucleic Acids Research
S BöhmH W Mewes

Abstract

The PROSITE pattern Zinc_Finger_C2H2 was extended to permit the detection of all C2H2 zinc fingers and their parent proteins in the recently completed sequence of the yeast genome. Additionally, a new computer program was written that extracts other zinc binding motifs (non C2H2 'fingers'), overlapping with the classical zinc finger pattern, from the found set of yeast C2H2 fingers. The complete and correct detection of all fingers is a prerequisite for the classification of the yeast zinc finger proteins in functional terms. The detected 53 yeast C2H2 zinc finger proteins do not contain finger clusters with 10 or more repeats, as is frequently found in higher eukaryotes. Only three proteins contain four or more fingers in a cluster. Moreover, nearly all 27 yeast proteins with tandem arrays of two or three finger domains can be classified into nine subgroups with high sequence conservation in their finger clusters, in particular of their DNA recognition helices. These results and application of the recently elaborated finger/DNA recognition rules suggest that the yeast proteins belonging to the same subgroup may recognize identical or very similar DNA sites.

References

Sep 1, 1992·Trends in Biochemical Sciences·B A ReddyP S Freemont
May 1, 1986·Molecular and Cellular Biology·E M McIntosh, R H Haynes
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M GribskovD Eisenberg
Jun 1, 1994·Nature Structural Biology·J W Schwabe, A Klug
Feb 1, 1995·Trends in Biochemical Sciences·R AaslandA F Stewart
Feb 1, 1994·Molecular Microbiology·Y LuoR C Deonier
Sep 1, 1996·Molecular and Cellular Biology·L L Lutfiyya, M Johnston
Sep 27, 1996·The Journal of Biological Chemistry·H StenmarkA D'Arrigo
Jun 1, 1996·Current Opinion in Structural Biology·K L Borden, P S Freemont
Nov 1, 1996·Nature Structural Biology·C A Kim, J M Berg
Feb 1, 1997·Current Opinion in Structural Biology·Y Choo, A Klug

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Citations

Jun 30, 2005·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Birgit KindermannHannelore Daniel
Mar 12, 2009·Plant Molecular Biology·Yidan OuyangQifa Zhang
Nov 22, 2011·Computers in Biology and Medicine·Shih-Yen Ku, Yuh-Jyh Hu
Jul 31, 2003·Journal of Molecular Biology·Deborah B Schulman, David R Setzer
Jul 15, 1999·Computers & Chemistry·M Q Zhang
Feb 7, 2001·Current Opinion in Microbiology·R A ClaytonC M Fraser
Sep 13, 2011·The Journal of Biological Chemistry·Noelia NunezMerlin Crossley
Mar 4, 2011·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Delphine GourcilleauNathalie Leblanc-Fournier
Jun 28, 2002·Nucleic Acids Research·Deborah B Schulman, David R Setzer
Oct 16, 2007·Applied and Environmental Microbiology·Raffaele De NicolaPascale Daran-Lapujade
Jul 27, 2002·Journal of Bacteriology·Ashley J Worlock, Ronald L Smith
Dec 18, 2002·Journal of Bacteriology·Andreia M Caldwell, Ronald L Smith
Feb 13, 2002·Molecular and Cellular Biology·Laura L NewcombWarren Heideman
Mar 10, 2006·Microbiology and Molecular Biology Reviews : MMBR·George M Santangelo
Jun 11, 2004·Annual Review of Biochemistry·Jessica E Smotrys, Maurine E Linder
Aug 26, 1998·Annual Review of Nutrition·D J Eide
Jul 2, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cheryl A KellerBernhard Lüscher
Jul 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·T J LyonsD J Eide
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·N GrotzD Eide
Oct 4, 2014·BMC Genomics·Matthew J Edmonds, Alan Morgan
Feb 12, 1998·The Journal of Cell Biology·C W EspelinP K Sorger
Sep 28, 2005·The Journal of Cell Biology·Jessica E SmotrysMaurine E Linder
Apr 29, 1998·FEBS Letters·I MendizabalI F de Larrinoa
Mar 8, 2008·Biochemical and Biophysical Research Communications·Soo Young ChoYoung Seek Lee

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