PMID: 11325465Apr 28, 2001Paper

Variations within hepatitis C virus E2 protein and response to interferon treatment

Virus Research
S Lo, H H Lin

Abstract

To determine whether the hepatitis C virus (HCV) E2 PePHD sequence (aa 659-670; PKR-eIF2alpha phosphorylation homology domain) is the determinant for the response of interferon treatment, we have analyzed PePHD sequences in HCV-infected patients who had received interferon-alfa treatment. The PePHD sequence from all (6/6) of the patients, who are non- or partial responders to the interferon treatment, is the wild-type sequence (RSELSPLLL-TT, consensus sequence of HCV-1a and HCV-1b). However, there are sequence variations from more than half (5/9) of the patients, who are complete responders to the treatment. We have also analyzed the NS5A ISDR sequence (aa 2209-2248, interferon sensitivity-determining region) variation in HCV-1b-infected patients. No such correlation has been observed. Thus, our data suggest that HCV E2 should play a more important role than NS5A in determining the interferon responses.

References

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Citations

May 8, 2003·Journal of Biosciences·Nicole Pavio, Michael M C Lai
Feb 8, 2005·Journal of Clinical Microbiology·Catherine GaudyAlain Goudeau
Dec 19, 2002·International Reviews of Immunology·Christopher F Basler, Adolfo García-Sastre
Feb 28, 2004·Liver International : Official Journal of the International Association for the Study of the Liver·Sheng-Shun YangJia-Horng Kao
Mar 9, 2010·Memórias do Instituto Oswaldo Cruz·Fernanda de Mello MaltaJoão Renato Rebello Pinho
May 1, 2007·Archives of Biochemistry and Biophysics·Johannes G BodeDieter Häussinger

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