PMID: 9531661Jun 13, 1998Paper

Varicella pneumonitis: clinical presentation and experience with acyclovir treatment in immunocompetent adults

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
N El-DaherR F Betts

Abstract

Cases of varicella pneumonitis were reviewed to examine the effects of acyclovir therapy on outcome. A retrospective chart review was done of all admissions of adults to two hospitals, between 1985 and 1995, because of complications of chickenpox. Fifteen patients were hospitalized for varicella pneumonitis during this period. No patient had a history of chickenpox as a child; all had a recent history (within 2-4 weeks prior to admission) of exposure to chickenpox in their family or neighborhood and developed respiratory symptoms 1 to 4 days after the appearance of the rash. Twelve patients (80%) had a history of cigarette smoking, and seven patients had a platelet count below the normal range. All patients were treated with intravenous acyclovir within 24 hours of admission, and all but one survived and were discharged from the hospital without comorbid conditions. The one mortality was attributed to bacterial superinfection. Acyclovir treatment may be of benefit for varicella pneumonitis, but no controlled trial has been performed to definitively answer this question.

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Citations

Jan 1, 2009·BMJ Case Reports·Michael Vaclav HolmesGabrielle Slapak
Jan 14, 2005·Internal Medicine·Takeshi Kaneko, Yoshiaki Ishigatsubo
Oct 1, 2007·Annals of Thoracic Medicine·Mohammed Alanezi
Nov 4, 2004·European Journal of Internal Medicine·Christos Y Frangides, Ioannis Pneumatikos
Jun 5, 2002·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Mirjana PoparaMervin Mer
Jul 1, 2010·Medical Journal, Armed Forces India·N BajajS Bajaj
Oct 12, 2004·The Journal of Infection·V C C ChengK Y Yuen
Dec 25, 2017·BMJ Case Reports·Annalan Mathew Dwight NavaratnamAza Abdulla
Nov 28, 2013·Pediatric Dermatology·Alanna F Bree, Elaine C Siegfried
Jan 16, 2021·Journal of Pharmaceutical Sciences·Maria Silvia Gurgel AssisAndré Luís Morais Ruela

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