Varicella vaccination in children with inflammatory bowel disease receiving immunosuppressive therapy.

Journal of Pediatric Gastroenterology and Nutrition
Ying Lu, Athos Bousvaros

Abstract

Children with inflammatory bowel disease (IBD) are often receiving chronic immunosuppressive therapy to stay in clinical remission; however, these therapies also put patients at risk for infections. Therefore, it is important to immunize children to minimize vaccine-preventable infections. However, there is a paucity of data on immune response to vaccines in patients with IBD. Current guidelines recommend that patients with IBD receive inactivated vaccines but suggest against immunizing immunosuppressed patients having IBD with live vaccines such as varicella. Unfortunately, the recommendation to not vaccinate with varicella was not based on any data. We present a case series of children with IBD receiving immunosuppressive therapy who tolerated and had a good immune response to varicella vaccine. We also review the literature and demonstrate that studies in other immunocompromised populations suggest that varicella vaccine is generally well tolerated and immunogenic. We also argue that it is important to weigh the benefits against risks with individual patients having IBD to decide whether varicella vaccination should be considered. Additional studies evaluating the safety and immunogenicity of varicella vaccine in patients wi...Continue Reading

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Citations

Apr 21, 2012·Journal of Pediatric Gastroenterology and Nutrition·Paul A RufoWilliam A Faubion
Feb 18, 2015·Advances in Medical Sciences·Aleksandra BanaszkiewiczPiotr Albrecht
Feb 2, 2016·The Journal of Pediatrics·Daniel J Adams, Cade M Nylund
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Sep 17, 2014·Vaccine·Susanna EspositoMaurizio Moggio
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Dec 6, 2017·World Journal of Gastroenterology : WJG·Huyen-Tran NguyenPatricia C Fulkerson
Sep 8, 2016·World Journal of Gastrointestinal Pharmacology and Therapeutics·Gianluca AndrisaniLuisa Guidi
Jun 28, 2020·Journal of Crohn's & Colitis·Philipp SchreinerLuc Biedermann
Jun 20, 2020·Journal of Pediatric Gastroenterology and Nutrition·Łukasz DembińskiAleksandra Banaszkiewicz
May 22, 2020·Current Rheumatology Reports·Nataša Toplak, Yosef Uziel
Apr 21, 2011·Journal of Pediatric Gastroenterology and Nutrition·Faazia AnsariSusan S Baker
Jan 11, 2017·The American Journal of Gastroenterology·Francis A FarrayeSunanda V Kane
May 5, 2020·Frontiers in Immunology·Claudia Bettoni da Cunha-RiehmMeinolf Suttorp
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Feb 22, 2011·Expert Review of Vaccines·Nigel W CrawfordJim P Buttery
Apr 22, 2011·Scandinavian Journal of Gastroenterology·Volker WilckensChristian Maaser

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