Varicella vaccination in pediatric oncology patients without interruption of chemotherapy

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Marianne D van de WeteringTaco W Kuijpers

Abstract

Morbidity and mortality from primary varicella-zoster virus (VZV) infection is increased in immunocompromised children. Vaccination of VZV-seronegative cancer patients with live-attenuated varicella vaccine is safe when chemotherapy is interrupted. However, VZV vaccination without interruption of chemotherapy would be preferable. To vaccinate VZV-seronegative pediatric oncology patients with live-attenuated VZV vaccine without interrupting their chemotherapy. We performed a single-center prospective cohort study. Thirty-one patients with either a hematological malignancy (n=24) or a solid tumor (n=7) were vaccinated early during their course of chemotherapy. VZV IgG seroconversion occurred in 14 of the 31 patients (45%) after one vaccination. Only 20 patients were revaccinated after 3 months. These were patients who did not seroconvert (5 patients) and patients who serocoverted (15 patients) to induce or sustain seropositivity. Of these 20 patients the final seroconversion rate was 70%. Seven out of the 31 patients (23%) developed a mild rash of which 5 were treated with antivirals and recovered completely without interrupting chemotherapy, and 2 recovered untreated. Of these 31 immunized patients 26 were available for cellular...Continue Reading

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Citations

Jun 7, 2019·Journal of Clinical Microbiology·Elizabeth McLachlanUNKNOWN Immunity of Canadians and Risk of Epidemics (iCARE) Laboratory Group and the Canadian Immunization Research Network (CIRN)
Feb 13, 2019·The Lancet Infectious Diseases·Malgorzata MikulskaUNKNOWN European Conference on Infections in Leukaemia group

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