Varicella vaccine effectiveness in the US vaccination program: a review

The Journal of Infectious Diseases
Jane SewardMarietta Vázquez

Abstract

Varicella vaccine (Varivax, Merck) has been available in the United States since 1995. We reviewed published results of postlicensure studies of vaccine effectiveness. Among 19 studies, 17 reported on the effectiveness of vaccine received before exposure, and 2 reported on effectiveness after exposure. Studies used retrospective and prospective cohort, case-control, and secondary attack rate (household contact) designs. The majority of estimates assessed protection against clinically diagnosed varicella. One dose of varicella vaccine was 84.5% effective (median; range, 44%-100%) in preventing all varicella and 100% effective (mean and median) in preventing severe varicella. When administered after exposure, varicella vaccine was highly effective in preventing or modifying varicella. Although 1 dose of varicella vaccine has provided excellent protection, a higher degree of effectiveness is needed in order to interrupt transmission and to prevent outbreaks in settings with high contact rates. Monitoring the effectiveness of the newly recommended 2-dose childhood vaccine schedule for varicella vaccine is a priority.

References

Jan 1, 1992·The Pediatric Infectious Disease Journal·C J WhiteP J Provost
May 31, 1984·The New England Journal of Medicine·R E WeibelE B Buynak
Oct 1, 1995·The Journal of Pediatrics·P R Krause, D M Klinman
Jan 1, 1994·American Journal of Epidemiology·P E Fine, E R Zell
Apr 16, 1998·The Pediatric Infectious Disease Journal·M B Salzman, C Garcia
Dec 23, 1999·The Pediatric Infectious Disease Journal·S BlackH Guess
Dec 23, 1999·The Pediatric Infectious Disease Journal·D A ClementsE B Walter
Jan 5, 2000·Pediatrics·B WatsonR Levenson
Mar 29, 2001·The New England Journal of Medicine·M VázquezE D Shapiro
Feb 7, 2002·JAMA : the Journal of the American Medical Association·Jane F SewardMelinda Wharton
Jun 13, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mark S DworkinJohn R Lumpkin
Jun 29, 2002·The Journal of Infectious Diseases·Karin GalilJane Seward
Dec 13, 2002·The New England Journal of Medicine·Karin GalilJane Seward
Aug 23, 1962·The New England Journal of Medicine·A H ROSS
Feb 12, 2004·The Pediatric Infectious Disease Journal·Barbara KuterUNKNOWN Study Group for Varivax
Feb 19, 2004·JAMA : the Journal of the American Medical Association·Marietta VázquezEugene D Shapiro
Mar 3, 2004·Pediatrics·Barna D TugwellPaul R Cieslak
Jul 10, 2004·The Journal of Infectious Diseases·Brian R LeeKristen R Ehresmann
Aug 12, 2004·JAMA : the Journal of the American Medical Association·Jane F SewardAisha O Jumaan
Feb 4, 2005·The New England Journal of Medicine·Huong Q NguyenJane F Seward
Aug 12, 2005·The Pediatric Infectious Disease Journal·Henry ShinefieldBarbara J Kuter
Aug 12, 2005·The Pediatric Infectious Disease Journal·Henry ShinefieldUNKNOWN Dose Selection Study Group for Proquad
Aug 18, 2005·JAMA : the Journal of the American Medical Association·Fangjun ZhouAbigail Shefer
Mar 16, 2007·The New England Journal of Medicine·Sandra S ChavesJane F Seward

❮ Previous
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Citations

Jul 3, 2013·Travel Medicine and Infectious Disease·Jaffar A Al-TawfiqZiad A Memish
Oct 3, 2009·Epidemiology and Infection·M KarhunenK Auranen
Dec 16, 2010·Epidemiology and Infection·M HöhleR Von Kries
Oct 1, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Samir S ShahJames E Levin
Jan 7, 2011·The Journal of Infectious Diseases·Eugene D ShapiroAnne A Gershon
Aug 2, 2012·The Journal of Infectious Diseases·Amra UzicaninUNKNOWN Maine 2009 Influenza A (H1N1) Vaccine Effectiveness Evaluation Group
Apr 14, 2011·BMC Public Health·Chao-Chih LaiDonald Dah-Shyong Jiang
May 30, 2009·BMC Medicine·Paolo BonanniPeter Wutzler
Jun 10, 2010·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Kevin PottieUNKNOWN coauthors of the Canadian Collaboration for Immigrant and Refugee Health
Aug 24, 2013·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·M García CenozA Barricarte
Dec 30, 2011·Journal of Neurovirology·Paul R Kinchington, William F Goins
Apr 4, 2013·American Journal of Epidemiology·Giorgio GuzzettaPiero Manfredi
Mar 12, 2016·Revista paulista de pediatria : orgão oficial da Sociedade de Pediatria de São Paulo·Maki HiroseSelma Lopes Betta Ragazzi
Jul 2, 2015·Archives of Disease in Childhood·Sophie BlumentalUNKNOWN Belgian Group for Varicella
Jun 22, 2010·Vaccine·F Marchetti, M Cuccia
May 12, 2010·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·J Marès BermúdezUNKNOWN Comité Asesor de Vacunas de la Asociación Española de Pediatría
Apr 13, 2010·The Journal of Infection·So Hee KimEun Hwa Choi
Mar 6, 2016·Vaccine·Tetsushi YoshikawaMasahiro Ohashi
Apr 22, 2015·Neurology Research International·Farhang BabamahmoodiAbdolreza Babamahmoodi
Dec 23, 2008·Seminars in Fetal & Neonatal Medicine·Candice K Smith, Ann M Arvin
Jul 11, 2012·Journal of Travel Medicine·Elaine H CramerAndrew Ganzon
Apr 2, 2009·Dermatologic Therapy·Rosella CreedParisa Ravanfar
Jun 27, 2012·Journal of Public Health Dentistry·Lawrence D RobertsonJohn M Symington
Feb 1, 2013·Journal of Medical Virology·Kenji TanimuraHideto Yamada
Sep 26, 2015·Journal of the Pediatric Infectious Diseases Society·Jessica Leung, Rafael Harpaz
Jun 15, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Jiye FuTianwei Ma
Apr 18, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·T HeikkinenT Vuorinen
Jan 18, 2013·Human Vaccines & Immunotherapeutics·Manuel García CenozJesús Castilla
Jul 4, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Arely Vergara-CastañedaGilberto Vaughan
Nov 15, 2011·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·M GuidoUNKNOWN Seroepidemiology Group
Dec 19, 2014·American Journal of Public Health·Margaret K DollChristopher M Zimmerman
Mar 5, 2015·Vaccine·Anette SiedlerBernhard Ehlers
Oct 22, 2011·Vaccine·Francesca PozzaLeonardo Emberti Gialloreti

❮ Previous
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