Varicella-zoster virus infection of human neural cells in vivo

Proceedings of the National Academy of Sciences of the United States of America
Armin BaikerAnn Arvin

Abstract

Varicella-zoster virus (VZV) establishes latency in sensory ganglia and causes herpes zoster upon reactivation. These investigations in a nonobese diabetic severe combined immunodeficient mouse-human neural cell model showed that VZV infected both neurons and glial cells and spread efficiently from cell to cell in vivo. Neural cell morphology and protein synthesis were preserved, in contrast to destruction of epithelial cells by VZV. Expression of VZV genes in neural cells was characterized by nuclear retention of the major viral transactivating protein and a block in synthesis of the predominant envelope glycoprotein. The attenuated VZV vaccine strain retained infectivity for neurons and glial cells in vivo. VZV gene expression in differentiated human neural cells in vivo differs from neural infection by herpes simplex virus, which is characterized by latency-associated transcripts, and from lytic VZV replication in skin. The chimeric nonobese diabetic severe combined immunodeficient mouse model may be useful for investigating other neurotropic human viruses.

References

Aug 1, 1992·The Journal of Infectious Diseases·A A GershonS Silverstein
Sep 6, 1990·The New England Journal of Medicine·R MahalingamD Gilden
Jan 15, 1988·International Journal of Cancer. Journal International Du Cancer·A NiiT Ogura
Aug 1, 1985·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·K Valnes, P Brandtzaeg
Apr 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·T PatelS H Kaufmann
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·R MahalingamD H Gilden
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·P G KennedyJ W Gow
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·O LunguS J Silverstein
Feb 17, 1999·Frontiers in Bioscience : a Journal and Virtual Library·P R Kinchington
Feb 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·B L DavidsonJ A Chiorini
Mar 4, 2000·The New England Journal of Medicine·D H GildenR J Cohrs
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·N UchidaI L Weissman
Sep 3, 2002·Journal of Neuroscience Research·Stanley TamakiNobuko Uchida
Mar 11, 2003·Journal of Medical Virology·Jason J ChenMichael D Gershon
May 28, 2003·Journal of Virology·Randall J CohrsPeter G E Kennedy

❮ Previous
Next ❯

Citations

May 3, 2005·Current Opinion in Infectious Diseases·Sophie Hambleton
Apr 29, 2011·Journal of Virology·Subbiah PugazhenthiDon Gilden
Apr 6, 2007·Journal of Virology·Kavitha GowrishankarAllison Abendroth
Dec 28, 2005·Journal of Virology·Chantelle HoodAllison Abendroth
Sep 7, 2013·Viruses·Nicholas L BairdDon Gilden
Apr 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Leigh ZerboniAnn M Arvin
Dec 13, 2012·Journal of Neurovirology·Xiaoli YuDon Gilden
Aug 21, 2013·Immunological Reviews·Daniel R GettsStephen D Miller
Oct 16, 2013·International Journal of Cancer. Journal International Du Cancer·Seung-Tae LeeJoseph Wiemels
Mar 19, 2014·Clinical Neurology and Neurosurgery·Julio SoteloJosé Flores
Oct 5, 2013·Clinical Microbiology Reviews·Anne A Gershon, Michael D Gershon
Jun 23, 2006·Reviews in Medical Virology·Mark Quinlivan, Judith Breuer
Mar 5, 2019·Vestnik oftalmologii·S E AvetisovA L Sidamonidze
Apr 5, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Janet E McElhaneyGraham Pawelec
Feb 11, 2020·Frontiers in Immunology·Chelsea GeradaAllison Abendroth
Jun 2, 2016·Journal of Neurovirology·Amy C KellerRandall J Cohrs

❮ Previous
Next ❯

Related Concepts

Related Feeds

CZI Human Cell Atlas Seed Network

The aim of the Human Cell Atlas (HCA) is to build reference maps of all human cells in order to enhance our understanding of health and disease. The Seed Networks for the HCA project aims to bring together collaborators with different areas of expertise in order to facilitate the development of the HCA. Find the latest research from members of the HCA Seed Networks here.