Varicella-zoster virus influences the activities of components and targets of the ERK signalling pathway

The Journal of General Virology
Markus RahausManfred H Wolff

Abstract

Varicella-zoster virus (VZV) is ultimately dependent upon its host cell for replication. To ensure its reproduction, VZV reorganizes various cellular functions by taking advantage of pre-existing signalling pathways. Recently, it was demonstrated that the activation of stress-related mitogen-activated protein kinase pathways following infection led to increased phosphorylation of cellular transcription factors involved in VZV gene expression. Here, it was shown that members of the extracellular signal-regulated kinase (ERK) pathway are also influenced following VZV infection: c-Raf remained inactive in infected MeWo cells, whereas MEK1/2 and ERK1/2 were phosphorylated transiently, reaching their highest level of phosphorylation at between 10 and 12 h post-infection. Inhibition of this pathway resulted in a severe reduction in viral progeny and in an increased apoptotic response, indicating that the functionality of this cascade is essential for successful high-rate replication. In addition, the activities of Bad, a cytoplasmic target of ERK via ribosomal S6 kinase, and the nuclear-localized target c-Myc were analysed. Bad is a member of the Bcl-2 family and has a key function in regulating apoptosis. Pro-apoptotic functions of ...Continue Reading

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Citations

Dec 11, 2007·Medical Microbiology and Immunology·Nathalie DeslogesManfred H Wolff
Jul 30, 2011·Future Virology·Christopher M TraylenShaw M Akula
Jul 8, 2011·Archives of Virology·Marcelo H A de FreitasCláudio A Bonjardim
Mar 23, 2010·Biochimica Et Biophysica Acta·Harilaos FilippakisGeorge Sourvinos
Feb 11, 2020·Frontiers in Immunology·Chelsea GeradaAllison Abendroth
Jan 12, 2021·BioMed Research International·Tapan Kumar MohantaPaola Defilippi

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