Varicella-zoster virus seroprevalence in children and adolescents in the pre-varicella vaccine era, Germany

BMC Infectious Diseases
Miriam Wiese-PosseltChristina Poethko-Müller

Abstract

In 2004, universal childhood varicella vaccination was introduced in Germany. We aimed to determine the age-specific prevalence of anti-varicella zoster virus (VZV) IgG-antibodies among children in the pre-varicella vaccine era in Germany, to identify factors associated with VZV seropositivity, and to assess the suitability of a commercially available ELISA for VZV seroepidemiological studies by comparing it with an in-house fluorescent antibody to membrane antigen test (FAMA) as the gold standard. Serum samples of 13,433 children and adolescents aged 1-17 years included in the population-based German Health Interview and Examination Survey for Children and Adolescents (KiGGS; conducted 2003-2006) were tested for anti-VZV IgG by ELISA. All samples with equivocal ELISA results and a random selection of ELISA-negative and -positive samples were tested by FAMA. Statistical analyses were conducted using a weighting factor adjusting the study population to the total population in Germany. Seroprevalences were calculated as percentages (%) with a 95% confidence interval (CI). Odds ratios (OR) were computed by multivariate logistic regression to determine the association between socio-demographic factors and VZV seropositivity. The VZ...Continue Reading

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Citations

Aug 22, 2018·Human Vaccines & Immunotherapeutics·Desirée Van OorschotDesmond Curran
Aug 19, 2020·The Journal of Infectious Diseases·Andrew N BubakMaria A Nagel
Sep 25, 2020·Expert Review of Vaccines·Florence KauffmannPeter Wutzler
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Jul 5, 2018·Medical Microbiology and Immunology·Annemarie Berger, Hans Wilhelm Doerr
Feb 23, 2021·Ocular Immunology and Inflammation·Aleksandra RadosavljevicManfred Zierhut

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Methods Mentioned

BETA
enzyme-linked immunosorbent assays
ELISA

Software Mentioned

SPSS

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