Varicella-Zoster virus-specific cell-mediated immunity in HIV-infected children receiving highly active antiretroviral therapy

The Journal of Infectious Diseases
Adriana WeinbergMyron J Levin

Abstract

Herpes zoster (HZ) is a frequent complication of advanced human immunodeficiency virus (HIV) infection. We determined the effect of highly active antiretroviral therapy (HAART) on reconstitution of varicella-zoster virus (VZV)-specific cell-mediated immunity (VZV-CMI) in 56 VZV- and HIV-infected children. VZV-CMI did not change over the course of >/=3 years of observation, despite a reduction in HIV load. VZV-CMI correlated with lower HIV load but not with CD4 cell percentage. The incidence of HZ was unaffected by HAART. None of 5 patients who developed HZ during the study had VZV-CMI before developing HZ. After developing HZ, only the 2 HAART-compliant patients developed VZV-CMI. Thus, VZV-specific immune reconstitution in HIV infection may require antigenic reexposure, in addition to control of HIV replication.

Associated Clinical Trials

Citations

Feb 23, 2010·The Journal of Infectious Diseases·Adriana WeinbergMyron J Levin
Mar 21, 2006·AIDS Research and Human Retroviruses·Adriana WeinbergMyron J Levin
Oct 12, 2010·AIDS Research and Human Retroviruses·Laura EnomotoAdriana Weinberg
Mar 23, 2011·AIDS Research and Human Retroviruses·Nathalie De CastroJean-Michel Molina
Mar 29, 2006·The Pediatric Infectious Disease Journal·Saro H ArmenianJoseph A Church
Jun 30, 2009·The Pediatric Infectious Disease Journal·Anne A GershonUNKNOWN Pediatric AIDS Clinical Trials Group 391 Team
Jan 10, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Myron J LevinUNKNOWN PACTG/IMPAACT 219C Team
Dec 16, 2011·Journal of Virology·Adriana WeinbergMyron J Levin
May 25, 2005·Pediatric Transplantation·Lise WarmingtonJoan L Robinson
Jan 21, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sophie GrabarUNKNOWN French Hospital Database on HIV (FHDH-ANRS CO4 Cohort)
Oct 17, 2007·Pediatrics·Mark J AbzugUNKNOWN International Maternal Pediatric Adolescent AIDS Clinical Trials Group P1024 Protocol Team
Dec 19, 2007·Pediatrics·Sarah M WoodRichard M Rutstein

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