Various immunological phenotypes are associated with increased airway responsiveness

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
U HerzH Renz

Abstract

Bronchial asthma is characterized by a TH2 type immune response, chronic inflammation of the airways and increased airway responsiveness. The relationship between IgE- and inflammatory-dependent mechanisms that contribute to bronchial asthma are not well defined. The purpose of this study was to compare and analyse the immune pathways that resulted in development of allergen-induced and/or inflammatory dependent increased airways responsiveness. BALB/c and C57BL/6 mice responded to OVA-sensitization with elevated allergen-specific IgE/IgG1 serum antibody-titres and the development of cutaneous immediate-type hypersensitivity reactions. Increased airway responsiveness was observed following airway allergen challenges. However, the inflammatory component of the lung differed between the strains. In OVA-sensitized BALB/c mice a marked increase in lymphocytes, eosinophils and neutrophils in BAL fluids was parallelled with elevated production of IL-4, IL-5 and TNFalpha in the lung. In contrast in OVA-sensitized C57BL/6 mice, the inflammatory immune response in the lung was much weaker. We postulate that two pathways can regulate the induction of increased airway responsiveness. One depends on the presence of allergen-specific IgE/Ig...Continue Reading

References

May 1, 1992·The Journal of Allergy and Clinical Immunology·D H BroideS I Wasserman
Jan 1, 1992·British Medical Bulletin·A B Kay, C J Corrigan
Jan 1, 1991·Annual Review of Immunology·A HermanA M Pullen
Mar 1, 1991·The American Review of Respiratory Disease·S T HolgateM K Church
Oct 11, 1990·The New England Journal of Medicine·J BousquetP Godard
Feb 1, 1990·The Journal of Allergy and Clinical Immunology·G J Gleich
May 1, 1974·The British Journal of Dermatology·J J LeydenA M Kligman
May 1, 1995·American Journal of Respiratory and Critical Care Medicine·J G ZangrilliS P Peters
Nov 1, 1995·American Journal of Respiratory Cell and Molecular Biology·V GoddingW W Busse
Jul 1, 1995·American Journal of Respiratory Cell and Molecular Biology·A J CoyleG P Anderson
Apr 1, 1995·American Journal of Respiratory Cell and Molecular Biology·T T KungR W Chapman
Mar 1, 1995·American Journal of Respiratory Cell and Molecular Biology·G BrusselleR Pauwels
Jun 1, 1994·American Journal of Respiratory Cell and Molecular Biology·S H GavettM Wills-Karp
Sep 1, 1994·International Archives of Allergy and Immunology·T T KungA S Watnick
May 1, 1994·American Journal of Respiratory Cell and Molecular Biology·N W LukacsS L Kunkel
Jan 1, 1993·The Journal of Clinical Investigation·J SalogaE W Gelfand
Feb 2, 1996·The Journal of Biological Chemistry·J E HuntN Ghildyal
May 1, 1996·American Journal of Respiratory Cell and Molecular Biology·D I BlythD Fattah
Jul 1, 1996·American Journal of Respiratory Cell and Molecular Biology·T B CasaleS J Galli
Mar 1, 1997·American Journal of Respiratory and Critical Care Medicine·E HamelmannE W Gelfand

❮ Previous
Next ❯

Citations

Mar 29, 2002·Current Allergy and Asthma Reports·Claus BachertPaul van Cauwenberge
Feb 14, 2004·Methods : a Companion to Methods in Enzymology·Udo HerzUrsula Wiedermann
Nov 8, 2001·European Journal of Pharmacology·H Renz
Aug 31, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·K P Leong, D P Huston
May 25, 2002·Allergy·C BachertP van Cauwenberge
Mar 5, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Danya LiuJacek Hawiger
Jul 16, 2004·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Jae Chang LeeChul Ho Jang
Jul 2, 2011·International Archives of Allergy and Immunology·Sebastian KerzelMichael Zemlin
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·J C KipsR A Pauwels
Sep 17, 2002·American Journal of Respiratory and Critical Care Medicine·Günter PäthHarald Renz
Nov 18, 2006·American Journal of Respiratory and Critical Care Medicine·Yoichi ChidaChiharu Kubo
Sep 30, 1999·American Journal of Respiratory Cell and Molecular Biology·A BraunH Renz
Mar 1, 2000·American Journal of Respiratory Cell and Molecular Biology·D A MarkP W Finn
Aug 2, 2000·American Journal of Respiratory Cell and Molecular Biology·U Neuhaus-SteinmetzH Renz
Jan 1, 2005·American Journal of Respiratory Cell and Molecular Biology·Monica Fonseca-AtenR Doug Hardy
Jan 24, 2003·American Journal of Respiratory Cell and Molecular Biology·Sebastian KerzelHarald Renz
Nov 10, 2009·The European Respiratory Journal·A M DittrichE Hamelmann
Jul 31, 2013·Respiratory Research·Marina A ShevchenkoAlexander M Sapozhnikov
Jan 6, 2012·Journal of Biomedicine & Biotechnology·Emilia Daniłowicz-LuebertSusanne Hartmann
Oct 9, 2003·Current Allergy and Asthma Reports·Claus BachertPaul Van Cauwenberge
Jul 27, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L Escoubet-LozachB Pipy
Apr 30, 2008·Inhalation Toxicology·Francesca AlessandriniWolfgang Kreyling
Apr 30, 2010·Experimental Lung Research·Kohei YamauchiHiroshi Inoue
Aug 6, 2011·The Journal of Allergy and Clinical Immunology·Ayşe KılıçHarald Renz
Aug 18, 2010·Journal of Ethnopharmacology·Maho SumiyoshiYoshiyuki Kimura
Nov 25, 2003·The Journal of Investigative Dermatology·Ralph RühlMargitta Worm
Jul 25, 2008·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Christina HartwigGeorg M N Behrens
Jul 14, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·O BacharL-O Cardell
Mar 24, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N BlümerH Renz
Mar 10, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·U HerzH Renz
Jun 10, 2003·Annals of the New York Academy of Sciences·Marek LommatzschHarald Renz
May 15, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M L ConradH Garn
Jul 18, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S SelA Dietrich
Feb 18, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S KerzelM Zemlin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

International Archives of Allergy and Applied Immunology
W ChenB W Manktelow
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
K Roberts, Z Jaffar
© 2022 Meta ULC. All rights reserved