Various oscillation patterns of serum fibroblast growth factor 21 concentrations in healthy volunteers.

Diabetes & Metabolism Journal
Sang Ah LeeMin-Seon Kim

Abstract

Fibroblast growth factor 21 (FGF21) was originally identified as a paroxysm proliferator activated receptor-α target gene product and is a hormone involved in metabolic regulation. The purpose of this study was to investigate the diurnal variation of serum FGF21 concentration in obese and non-obese healthy volunteers. Blood samples were collected from five non-obese (body mass index [BMI] ≤23 kg/m(2)) and five obese (BMI ≥25 kg/m(2)) healthy young men every 30 to 60 minutes over 24 hours. Serum FGF21 concentrations were determined by radioimmunoassay. Anthropometric parameters, glucose, free fatty acid, insulin, leptin, and cortisol concentrations were also measured. The serum FGF21 concentrations displayed various individual oscillation patterns. The oscillation frequency ranged between 6 and 12 times per day. The average duration of oscillation was 2.52 hours (range, 1.9 to 3.0 hours). The peaks and troughs of FGF21 oscillation showed no circadian rhythm. However, the oscillation frequency had a diurnal variation and was lower during the light-off period than during the light-on period (2.4 vs. 7.3 times, P<0.001). There was no difference in the total frequency or duration of oscillations between non-obese and obese subjects,...Continue Reading

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Citations

Jun 27, 2012·Current Opinion in Pediatrics·Daniel Cuevas-RamosFrancisco J Gómez-Pérez
Nov 17, 2015·Nature Reviews. Drug Discovery·Chiara DegirolamoAntonio Moschetta
Mar 1, 2012·Diabetes & Metabolism Journal·Ji A Seo, Nan Hee Kim
Sep 4, 2021·Journal of Sleep Research·Luiz Eduardo Mateus BrandãoJonathan Cedernaes

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