Various stress stimuli rewire the profile of liver secretome in a p53-dependent manner

Cell Death & Disease
Meital Charni-NatanV Rotter

Abstract

Liver is an important secretory organ that consistently manages various insults in order to retain whole-body homeostasis. Importantly, it was suggested that the tumor-suppressor p53 plays a role in a variety of liver physiological processes and thus it is being regarded as a systemic homeostasis regulator. Using high-throughput mass spectrometric analysis, we identified various p53-dependent liver secretome profiles. This allowed a global view on the role of p53 in maintaining the harmony of liver and whole-body homeostasis. We found that p53 altered the liver secretome differently under various conditions. Under physiological conditions, p53 controls factors that are related mainly to lipid metabolism and injury response. Upon exposure to various types of cancer therapy agents, the hepatic p53 is activated and induces the secretion of proteins related to additional pathways, such as hemostasis, immune response, and cell adhesion. Interestingly, we identified a possible relationship between p53-dependent liver functions and lung tumors. The latter modify differently liver secretome profile toward the secretion of proteins mainly related to cell migration and immune response. The notion that p53 may rewire the liver secretome p...Continue Reading

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Citations

Jul 19, 2019·Journal of Molecular Cell Biology·Yan SteinVarda Rotter
Jun 28, 2019·Frontiers in Endocrinology·Meital Charni-NatanVarda Rotter
Nov 8, 2020·Carcinogenesis·Yan SteinVarda Rotter

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Methods Mentioned

BETA
immunoprecipitation
PCR
FCS

Software Mentioned

mascot
GeneAnalytics
NIH ImageJ
QuPath
Genedata
Expressionist

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