Varying activity of chlorhexidine-based disinfectants against Klebsiella pneumoniae clinical isolates and adapted strains

The Journal of Hospital Infection
L J BockJ M Sutton

Abstract

Control of multi-drug-resistant (MDR) organisms relies increasingly on the use of biocides, including chlorhexidine, to limit the risk of infection. The concentration and formulation of chlorhexidine can vary hugely between products. To establish the activity of chlorhexidine and in-use chlorhexidine formulations against 14 clinical Klebsiella pneumoniae strains isolated before and since the use of chlorhexidine became routine, and strains that have adapted following sublethal chlorhexidine exposure. Minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of five chlorhexidine-containing formulations were measured at 5min, 15min, 30min and 24h for the panel of K. pneumoniae strains. After 5min, MBCs of five formulations varied from 0.006 to >50% working concentration (WC) or from 78 to 2500μg/mL chlorhexidine. For one formulation, MBCs were >50% WC for five of the 14 strains, and for another formulation, four of the 14 strains could resist 25% WC. NCTC 13368 was consistently most tolerant to chlorhexidine, whereas the strains isolated before the use of chlorhexidine became routine were more sensitive. One pre-chlorhexidine era and five modern strains increased MICs up to 16-fold following exposur...Continue Reading

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Citations

Feb 2, 2019·Archives of Disease in Childhood·Lucy Jane Bock
Aug 9, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ahmed BabikerMary K Hayden
May 1, 2018·Frontiers in Microbiology·Tsun S N KuSamuel A Lee
Apr 3, 2019·International Journal of Molecular Sciences·Maria D'AccoltiElisabetta Caselli
Jun 28, 2019·International Journal of Molecular Sciences·Pabulo H RampelottoRogério Margis
Jan 31, 2021·Microorganisms·Maria D'AccoltiElisabetta Caselli
Jul 1, 2020·International Journal of Antimicrobial Agents·Ruben BarretoStan Monstrey
Jun 26, 2021·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Moustafa A Tag ElDeinMona T Kashef
Jul 6, 2021·JAC-antimicrobial Resistance·Jean-Yves MaillardRose Cooper
Apr 21, 2018·Microbiology Spectrum·Jean-Yves Maillard

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