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Varying Effects of APOE Alleles on Extreme Longevity in European Ethnicities

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

Nov 13, 2019

Anastasia Gurinovichpaola sebastiani

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Abstract

APOE is a well-studied gene with multiple effects on aging and longevity. The gene has three alleles: e2, e3, and e4, whose frequencies vary by ethnicity. While the e2 is associated with healthy cognitive aging, the e4 allele is associated with Alzheimer's disease and early mortality an...read more

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Aging
Alleles
Alzheimer's Disease
Estrogens
Ethnic Group
Genes
Persons
Research Subject
Analysis
CERS2 protein, human
1
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Varying Effects of APOE Alleles on Extreme Longevity in European Ethnicities

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

Nov 13, 2019

Anastasia Gurinovichpaola sebastiani

PMID: 31724059

DOI: 10.1093/gerona/glz179

Abstract

APOE is a well-studied gene with multiple effects on aging and longevity. The gene has three alleles: e2, e3, and e4, whose frequencies vary by ethnicity. While the e2 is associated with healthy cognitive aging, the e4 allele is associated with Alzheimer's disease and early mortality an...read more

Mentioned in this Paper

Aging
Alleles
Alzheimer's Disease
Estrogens
Ethnic Group
1

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Paper Details
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