Varying relationship between 25-hydroxy-vitamin D, high density lipoprotein cholesterol, and serum 7-dehydrocholesterol reductase with sunlight exposure

Journal of Clinical Lipidology
Vivek G PatwardhanVaman V Khadilkar

Abstract

Cholesterol and cholecalciferol are synthesized from a common substrate 7-dehydrocholesterol. 7-dehydrocholesterol is converted to cholesterol by 7-dehydrocholesterol reductase enzyme (DHCR7) and to cholecalciferol by ultraviolet B radiation from sunlight. To examine the effect of sunlight exposure and serum DHCR7 levels on cholecalciferol and cholesterol levels and studying any interrelationship. In a cross-sectional observational study, 307 apparently healthy men (aged 40-60 years) were assessed for sunlight exposure, lipid levels, serum DHCR7, 25 hydroxyvitamin D (25(OH)D), body composition, and dietary milk calcium intake. Vitamin D deficiency (25(OH)D <20 ng/mL, 1 ng/mL = 2.496 nmols/L) was found in 56% of subjects. Serum 25(OH)D concentrations increased significantly with increasing duration of sunlight exposure (P < .05). At lower sunlight exposure (<1 h/d), serum 25(OH)D levels were positively associated with high-density lipoprotein cholesterol (HDL-C) levels (P < .05) but at moderate sunlight exposure (1-2 h/d), there was no significant association. However, with higher sunlight exposure (>2 h/d), serum 25(OH)D concentrations were significantly negatively associated with HDL-C (P < .05). At moderate and higher sunligh...Continue Reading

References

Apr 4, 2000·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·G M KiebzakZ Y Zhang
Sep 17, 2002·Methods : a Companion to Methods in Enzymology·Brian L Diffey
Mar 28, 2006·Journal of the American Society of Nephrology : JASN·Roberto TrevisanGiuseppe Lepore
Feb 21, 2009·Nature Clinical Practice. Endocrinology & Metabolism·Arshag D Mooradian
Sep 21, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Nidhi KadamVaman Khadilkar
Mar 9, 2011·Acta Dermato-venereologica·William G Tsiaras, Martin A Weinstock
Mar 11, 2011·European Journal of Endocrinology·Elisabeth WehrBarbara Obermayer-Pietsch
Jun 7, 2011·Progress in Lipid Research·Rolf Jorde, Guri Grimnes
Jun 11, 2011·The Open Cardiovascular Medicine Journal·C V RizosE N Liberopoulos
Aug 30, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·Natasja M van Schoor, Paul Lips

❮ Previous
Next ❯

Citations

Dec 24, 2016·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Shelley GormanMartin Feelisch
Feb 23, 2019·BMC Public Health·Karim H FarhatNahla K Ibrahim
Oct 21, 2016·Journal of Pediatric Endocrinology & Metabolism : JPEM·Judith BrodyMarianna Rachmiel
May 3, 2021·The Journal of Steroid Biochemistry and Molecular Biology·Spyridon N KarrasKalliopi Kotsa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Pediatric Endocrinology & Metabolism : JPEM
Annemieke M BootSabine M P F de Muinck Keizer-Schrama
The Journal of Clinical Endocrinology and Metabolism
Kristine E EnsrudOsteoporotic Fractures in Men Study Group
© 2021 Meta ULC. All rights reserved