Vasa, PL10, and Piwi gene expression during caudal regeneration of the polychaete annelid Alitta virens

Development Genes and Evolution
Vitaly V Kozin, Roman P Kostyuchenko

Abstract

Polychaetes are famous for their outstanding ability to regenerate lost body parts. Moreover, these worms possess a number of ancestral features in anatomy, development, and genetics, making them particularly suitable for comparative studies. Thus, fundamental as well as new undisclosed so far features of regenerative processes may be revealed, using polychaetes as a model. In the present work, we aimed to analyze the molecular basis of caudal regeneration in the nereid polychaete Alitta virens (formerly Nereis virens). We focused on homologues genes of RNA helicases Vasa and PL10 and ncRNA-binding proteins Piwi. These markers are suggested to play a significant role in maintenance of undifferentiated state of primordial germ cells and multipotent stem cells across invertebrates. In normal conditions, A. virens homologues of Vasa, PL10, and Piwi were differentially expressed in the subterminal growth zone and germline cells. Caudal amputation induced expression of studied genes de novo, which further accompanies all steps of regeneration. An early appearance of the transcripts in wound epithelium and internal blastemal cells suggests involvement of these genes in the well-known cell dedifferentiation events that assure polychae...Continue Reading

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Citations

Aug 10, 2016·Current Opinion in Genetics & Development·B Duygu Özpolat, Alexandra E Bely
Jun 29, 2017·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Liliana MilaniMaria Gabriella Maurizii
Aug 11, 2018·Evolution & Development·Guillermo Ponz-SegrellesM Teresa Aguado
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Mar 7, 2021·International Journal of Molecular Sciences·Kornélia BodóPéter Engelmann
Oct 8, 2021·Biological Reviews of the Cambridge Philosophical Society·Baruch RinkevichBert Hobmayer

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