Vasa Vasorum Densities in Human Carotid Atherosclerosis Is Associated with Plaque Development and Vulnerability

Journal of Korean Neurosurgical Society
Sung-Pil JooTae-Sun Kim

Abstract

The extensive vasa vasorum network functions as a conduit for the entry of inflammatory cells or factors that promote the progression of angiogenesis and plaque formation. Therefore, we investigated the correlation between the carotid vasa vasorum activities and carotid plaque vulnerability using indocyanine green video angiography (ICG-VA) during carotid endarterectomy (CEA). Sixty-nine patients who underwent CEA were enrolled prospectively from September 2015 to December 2017. During CEA, a bolus of ICG was injected intravenously before and after resecting the atheroma. Additionally, we performed immunohistochemistry using CD68 (a surface marker of macrophages), CD117 (a surface marker of mast cells), and CD4 and CD8 (surface markers of T-cells) antibodies to analyze the resected plaque specimens. The density of active vasa vasorum was observed in all patients using ICG-VA. The vasa vasorum externa (VVE) and interna (VVI) were seen in 11 (16%) and 57 patients (82.6%), respectively. Macroscopically, the VVE-type patterns were strongly associated with preoperative angiographic instability (81.8%, p=0.005) and carotid plaque vulnerability (90.9%, p=0.017). In contrast, the VVI-type patterns were weakly associated with angiograph...Continue Reading

References

Aug 15, 1991·The New England Journal of Medicine·UNKNOWN North American Symptomatic Carotid Endarterectomy Trial CollaboratorsM Eliasziw
Jan 1, 1997·The Journal of Pathology·J J Boyle
Nov 14, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·R T Lee, P Libby
Jan 14, 1999·The New England Journal of Medicine·R Ross
Jan 15, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·M L Grønholdt
Jul 10, 2001·The British Journal of Surgery·R MofidiT V Keaveny
Aug 24, 2002·Circulation Research·Göran K HanssonZhong-Qun Yan
Dec 20, 2002·Nature·Peter Libby
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Karen S MoultonJudah Folkman
Jan 18, 2005·Stroke; a Journal of Cerebral Circulation·Mark FisherJohn Norris
Apr 1, 2006·Stroke; a Journal of Cerebral Circulation·Zhi-Yong LiJonathan H Gillard
Jul 18, 2006·Journal of the American College of Cardiology·Steven B Feinstein
May 29, 2007·Journal of the American College of Cardiology·Brendan Doyle, Noel Caplice
Jul 17, 2007·Cardiovascular Research·Erik L Ritman, Amir Lerman
Feb 26, 2008·AJNR. American Journal of Neuroradiology·K YoshidaS Yamagata
Nov 9, 2011·Nature Medicine·Christian Weber, Heidi Noels
Aug 17, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Peter Libby
Nov 17, 2012·Cerebrovascular Diseases·Marie-Luise MonoMarwan El-Koussy
Feb 23, 2013·Cellular and Molecular Life Sciences : CMLS·Bart LegeinEsther Lutgens
Sep 5, 2013·Journal of Korean Neurosurgical Society·Hyung-Sik MoonTae-Sun Kim
Dec 3, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Hiroyuki KatanoSatoru Takahashi
Dec 31, 2014·Cerebrovascular Diseases·Angelika AlonsoMichael G Hennerici

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

GraphPad Prism
GraphPad
Image J

Related Concepts

Related Feeds

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.

Related Papers

Nederlands tijdschrift voor geneeskunde
van LIMBORGH
The American Journal of Pathology
C E Woodruff
American Journal of Physiology. Heart and Circulatory Physiology
Mary Jo Mulligan-Kehoe
© 2021 Meta ULC. All rights reserved