Vasa vasorum quantification in human varicose great and small saphenous veins

Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft
Zbyněk TonarKirsti Witter

Abstract

Recent research regarding saphenous vasa vasorum (VV) has focused on two main topics: the VV during varicogenesis in chronic venous insufficiency and the VV in saphenous grafts used in reconstructive vascular surgery. Our aim has been (i) to establish a technique for the histological quantification of the VV in human varicose great and small saphenous veins and (ii) to describe the density and distribution of the vasa vasorum within varicose veins. Great (n=11) and small (n=5) saphenous veins (length, 15-40cm) were collected from 12 patients who were undergoing venous stripping due to chronic venous insufficiency (Clinical-Etiology-Anatomy-Pathophysiology class 2-3). The veins were divided into 5-cm long segments. In total, 92 tissue blocks were collected to trace the variability of the density and distribution of the vasa vasorum in the proximo-distal direction. The endothelium was detected by immunohistochemistry using the von Willebrand factor. We quantified the number of microvessel profiles per section area and the relative distance of the microvessels from the outer border of the adventitia. The VV did not exhibit a preferential orientation in the varicose veins. VV density profiles were highest in the middle third of the...Continue Reading

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Citations

Nov 16, 2013·Lasers in Medical Science·Michal HegerMartin J C van Gemert
Feb 5, 2016·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Zbyněk TonarKirsti Witter
Mar 24, 2016·International Journal of Computer Assisted Radiology and Surgery·Miroslav JiříkVáclav Liška
Nov 28, 2013·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Petra KochováZbyněk Tonar
Aug 2, 2015·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Zbyněk TonarKirsti Witter
Jun 19, 2018·Cells, Tissues, Organs·Lucio Díaz-FloresJuan F Madrid
Apr 2, 2019·Phlebology·David KachlikVaclav Baca
Mar 26, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhongwen QiJunping Zhang

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