PMID: 9555560Apr 29, 1998Paper

Vasal reanastomosis using fibrin glue combined with sutures: which combination of sutures in a delayed protocol? Experimental study in rats

European Urology
O VankemmelE Mazeman

Abstract

The actual number of transmural sutures needed to ensure a successful fibrin-glued vasovasostomy is a key study parameter of the few experimental works already published. The present work was done to evaluate fibrin-glued vasovasostomy in rats in combination with only 2 transmural sutures. We compared the results to our previous study in which we demonstrated the efficiency of a combination of the use of fibrin glue with 3 sutures in comparison with a conventional microsurgical technique. Twenty Sprague-Dawley rats underwent bilateral vasectomy followed 2 weeks later by bilateral vasovasostomy using fibrin glue combined with 2 transmural sutures. Each animal was sacrificed 7 weeks postoperatively after a 3-week mating period with a Sprague-Dawley female rat, the vasal specimens were evaluated for sperm granuloma formation. Mean operative time and fertility rates were recorded. The combination of fibrin glue with 2 transmural sutures gave evidence of less successful performances than the combination with 3 transmural sutures and the conventional microsurgical technique for all parameters evaluated but the mean operative time. Our study underlines the need for a third transmural suture placed 120 degrees apart from the others whe...Continue Reading

Citations

Dec 22, 2004·Current Urology Reports·Dominick J Carbone, Joseph J Phillips
Sep 8, 2005·The Journal of Urology·Khai-Linh V HoSamuel Hakim
Jun 14, 2019·Proceedings·G Luke MachenErin T Bird
May 1, 2021·Fertility and Sterility·Richard J Fantus, Joshua A Halpern

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