PMID: 9447720Feb 3, 1998Paper

Vascular actions of 'caged' phenylephrine analogs depend on the structure and site of attachment of the 2-nitrobenzyl group

Journal of Photochemistry and Photobiology. B, Biology
W A BoyleJ M Nerbonne

Abstract

In the experiments presented in this article, the effects of four caged analogs of the alpha 1-adrenergic agonist phenylephrine (PE) on the properties of small (100-200 microns outer diameter), isolated rat mesenteric arteries were compared. The four caged PE analogs contained either an unsubstituted (analogs I and II) or an alpha-carboxy substituted (analogs III and IV) 2-nitrobenzyl group attached to the phenolic oxygen atom (O-linked; analogs II and IV) or to the amino group (N-linked; analogs I and III) of PE. The structure of each caged PE analog was confirmed by UV, IR and 1H NMR spectral analysis. For physiological experiments, photolysis of the caged PE analogs was accomplished with a Hi-Tech Scientific flashlamp, and vascular smooth muscle contraction was measured with a computer-based image analysis system. In some experiments, the fura-2 ratiometric technique was used to examine the effects of the caged PE analogs on intracellular Ca2+ levels. At concentration < or = 10(-6) M, none of the four analogs displayed measurable intrinsic vasoconstricting activity, that is, vasoconstrictions were only observed following light flashes, consistent with the release of free PE. At concentrations > or = 10(-5) M, however, both O...Continue Reading

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Feb 1, 1991·Circulation·D R HathawayR L Wilensky
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Citations

Feb 1, 1995·Journal of Photochemistry and Photobiology. B, Biology·S Muralidharan, J M Nerbonne
Sep 18, 2013·Biochimica Et Biophysica Acta·Xavier Deupi
Dec 12, 2012·Chemistry : a European Journal·Lutz F TietzeIngrid Schuberth
Oct 5, 2010·Critical Reviews in Microbiology·Louis Yi Ann ChaiPeter Warn
Jan 18, 2012·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Alexander G RussellJohn S Snaith
Nov 8, 2003·The Journal of Organic Chemistry·Alan R KatritzkyKeith R Bley

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