Vascular actions of endothelin in the rabbit kidney

Clinical and Experimental Pharmacology & Physiology
K M Denton, W P Anderson

Abstract

1. The effect of two doses of endothelin, 10 and 50 ng/kg per min, i.v., on glomerular filtration rate (GFR), tubular stop flow pressure and pre- and post-glomerular vascular resistance have been studied in anaesthetized rabbits. 2. Blood pressure did not change significantly in response to 10 ng/kg per min endothelin or vehicle infusion, but rose steadily during infusion of 50 ng/kg per min endothelin, increasing 11.8 +/- 2.7 mmHg by 90 min of infusion. 3. Glomerular filtration fraction (3H-inulin extraction ratio) rose and remained elevated throughout the endothelin infusion at 50 ng/kg per min. GFR did not change significantly until 70-90 min of the infusion (50 ng/kg per min) when it decreased by about 35%. No significant changes were seen at 10 ng/kg per min endothelin. 4. Sodium excretion rate rose in response to the lower dose, due to an increase in fractional sodium excretion. No changes in sodium excretion were seen at the higher dose of endothelin. 5. Glomerular capillary pressure rose significantly in response to endothelin infusion (50 ng/kg per min). 6. Renal blood flow fell progressively in response to endothelin (50 ng/kg per min), to about one-third of the pre-infusion value. 7. Renal vascular resistance increas...Continue Reading

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Citations

Oct 1, 1991·Pflügers Archiv : European journal of physiology·K M Denton, W P Anderson
Nov 1, 1994·General Pharmacology·Z S ErcanH Zengil
Jan 1, 1994·Clinical and Experimental Pharmacology & Physiology·I J ChristyW P Anderson
Apr 1, 1996·Clinical and Experimental Pharmacology & Physiology·D E Kohan
Aug 10, 2004·Clinical and Experimental Pharmacology & Physiology·Kate M DentonRoger G Evans
Mar 1, 1993·British Journal of Pharmacology·M E RogersonG H Neild
Jan 21, 2011·Physiological Reviews·Donald E KohanDavid M Pollock
Mar 1, 1993·The Journal of Clinical Investigation·D E Kohan, E Padilla
Jul 1, 1995·The Journal of Clinical Investigation·M A VernaceB M Wilkes
Aug 18, 2004·The Journal of Clinical Investigation·Dowhan AhnDonald E Kohan
Oct 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D E Kohan
Apr 2, 2009·European Journal of Clinical Investigation·W Neuhofer, D Pittrow
Feb 6, 1998·The Journal of Laboratory and Clinical Medicine·R L Miller, D E Kohan
Aug 1, 1996·The Journal of Urology·G A BogaertM A Heymann
Oct 1, 1992·Hypertension·S TélémaqueP D'Orléans-Juste
Sep 1, 1991·Hypertension·I J ChristyW P Anderson
Dec 26, 2001·Journal of the American Society of Nephrology : JASN·Kate M DentonWarwick P Anderson
Jan 1, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D E Kohan

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