Vascular Adaptation of the Right Ventricle in Experimental Pulmonary Hypertension

American Journal of Respiratory Cell and Molecular Biology
Brian B GrahamRubin M Tuder

Abstract

Optimal right ventricular (RV) function in pulmonary hypertension (PH) requires structural and functional coupling between the RV cardiomyocyte and its adjacent capillary network. Prior investigations have indicated that RV vascular rarefaction occurs in PH, which could contribute to RV failure by reduced delivery of oxygen or other metabolic substrates. However, it has not been determined if rarefaction results from relative underproliferation in the setting of tissue hypertrophy or from actual loss of vessels. It is also unknown if rarefaction results in inadequate substrate delivery to the RV tissue. In the present study, PH was induced in rats by SU5416-hypoxia-normoxia exposure. The vasculature in the RV free wall was assessed using stereology. Steady-state metabolomics of the RV tissue was performed by mass spectrometry. Complementary studies were performed in hypoxia-exposed mice and rats. Rats with severe PH had evidence of RV failure by decreased cardiac output and systemic hypotension. By stereology, there was significant RV hypertrophy and increased total vascular length in the RV free wall in close proportion, with evidence of vessel proliferation but no evidence of endothelial cell apoptosis. There was a modest inc...Continue Reading

References

Aug 3, 2005·The Journal of Clinical Investigation·Ichiro ShiojimaKenneth Walsh
Nov 16, 2007·Basic Research in Cardiology·Judith Christina EiseleChristian Mühlfeld
May 29, 2010·American Journal of Respiratory and Critical Care Medicine·Harm J BogaardNorbert F Voelkel
Feb 8, 2011·American Journal of Respiratory and Critical Care Medicine·Harm J BogaardNorbert F Voelkel
Jul 2, 2011·American Journal of Respiratory Cell and Molecular Biology·Jennifer I DrakeRamesh Natarajan
Mar 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Hong WeiGregg L Semenza
Apr 16, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Abdallah AlzoubiMasahiko Oka
Jun 25, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Lin PiaoStephen L Archer
Jul 3, 2013·American Journal of Respiratory Cell and Molecular Biology·Brian B GrahamRubin M Tuder
Jul 13, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Gopinath SutendraEvangelos D Michelakis
Aug 6, 2013·Cell·Katrien De BockPeter Carmeliet
Nov 19, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Michie TobaIvan F McMurtry
Nov 28, 2013·American Journal of Respiratory and Critical Care Medicine·Anna R HemnesJames West
Apr 4, 2015·The Canadian Journal of Cardiology·John J RyanStephen L Archer
Sep 10, 2015·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Todd M KolbPaul M Hassoun
Jan 15, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Xiao-Qing SunZhi-Cheng Jing
Apr 15, 2016·American Journal of Respiratory and Critical Care Medicine·Megha H TalatiAnna R Hemnes
Jun 22, 2016·Heart·Marc-André KörtenUNKNOWN Competence Network for Congenital Heart Defects Investigators
Jun 28, 2016·Echo Research and Practice·Garvan C KaneRobert B McCully
Mar 10, 2017·American Journal of Respiratory and Critical Care Medicine·Brian B GrahamRubin M Tuder
Apr 22, 2017·European Heart Journal·Cristel M Sørensen HjortshøjLars Søndergaard
Jul 14, 2017·Pulmonary Circulation·Mariana M ClavéAntonio A Lopes
Nov 4, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Andrea L FrumpTim Lahm
Jan 24, 2018·Circulation Research·Yosif ManavskiStefanie Dimmeler
Apr 27, 2018·Science Translational Medicine·Ekaterina LegchenkoGeorg Hansmann

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Citations

Jul 12, 2018·American Journal of Respiratory Cell and Molecular Biology·Todd M Kolb, Paul M Hassoun
Dec 26, 2018·Antioxidants & Redox Signaling·Victor TsengC Michael Hart
May 24, 2019·Circulation Research·Jason G E ZeltDuncan J Stewart
Apr 15, 2020·Cardiovascular Research·Robert D BrownKurt R Stenmark
Jun 20, 2020·Heart Failure Reviews·Yannick J H J TaverneDaphne Merkus
Aug 31, 2018·Frontiers in Cardiovascular Medicine·Jose L Izquierdo-GarciaJesus Ruiz-Cabello
Feb 6, 2021·Clinics in Chest Medicine·Aida Llucià-ValldeperasHarm J Bogaard
Mar 17, 2021·British Journal of Pharmacology·Joshua P DignamAdrian J Hobbs
Mar 30, 2019·Journal of the American College of Cardiology·Javier SanzRobert Naeije
Aug 5, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·Biruk KassaBrian B Graham

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Methods Mentioned

BETA
flow cytometry

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