Vascular and brain neuropeptide Y in banded and spontaneously hypertensive rats

Peptides
M MorrisL M D Delbridge

Abstract

Debate exists regarding the relative importance of neuropeptide Y (NPY) in the pathogenesis of genetic and non-genetic hypertension. NPY concentrations were compared in conduit, mesenteric and renal vasculatures and in hypothalamic and medullary regions of age-matched normotensive control, aortic banded and spontaneously hypertensive rats (SHRs). Lower NPY concentrations were measured in the pre-optic area of banded rats compared to controls and SHR. Renal vein NPY levels were reduced in banded animals, whereas renal artery levels were decreased in SHR. In mesenteric arteries, NPY concentration was selectively increased in SHR. These findings suggest that local hemodynamic alterations influence endogenous levels of this potent vasoconstrictor.

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Citations

Sep 26, 2006·Canadian Journal of Physiology and Pharmacology·Danielle JacquesChantale Provost
Jul 9, 2016·International Journal of Cardiology·Ping ZhuShu Lin
Nov 28, 2017·Chinese Medical Journal·Ying LiaoJun-Bao Du
May 15, 2020·World Journal of Pediatrics : WJP·Hong-Xia LiYue Yuan

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