Vascular branching point counts using photoacoustic imaging in the superficial layer of the breast: A potential biomarker for breast cancer

Photoacoustics
I YamagaMasakazu Toi

Abstract

This study aimed to identify the characteristics of the vascular network in the superficial subcutaneous layer of the breast and to analyze differences between breasts with cancer and contralateral unaffected breasts using vessel branching points (VBPs) detected by three-dimensional photoacoustic imaging with a hemispherical detector array. In 22 patients with unilateral breast cancer, the average VBP counts to a depth of 7 mm below the skin surface were significantly greater in breasts with cancer than in the contralateral unaffected breasts (p < 0.01). The ratio of the VBP count in the breasts with cancer to that in the contralateral breasts was significantly increased in patients with a high histologic grade (p = 0.03), those with estrogen receptor-negative disease (p < 0.01), and those with highly proliferative disease (p < 0.01). These preliminary findings indicate that a higher number of VBPs in the superficial subcutaneous layer of the breast might be a biomarker for primary breast cancer.

Citations

Mar 16, 2019·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Pankaj WarbalRatan K Saha
Jul 25, 2019·Disease Models & Mechanisms·Emma BrownSarah E Bohndiek
Mar 25, 2020·Biomedical Optics Express·Boudewijn van der SandenEric Lacot
Dec 20, 2019·Tissue Engineering. Part B, Reviews·Binita ShresthaEric M Brey
Jan 29, 2021·The Keio Journal of Medicine·Hiroki KajitaKazuo Kishi

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