Vascular cells contribute to atherosclerosis by cytokine- and innate-immunity-related inflammatory mechanisms

Innate Immunity
Harald LoppnowMichael Buerke

Abstract

Cardiovascular diseases are the human diseases with the highest death rate and atherosclerosis is one of the major underlying causes of cardiovascular diseases. Inflammatory and innate immune mechanisms, employing monocytes, innate receptors, innate cytokines, or chemokines are suggested to be involved in atherogenesis. Among the inflammatory pathways the cytokines are central players. Plasma levels of cytokines and related proteins, such as CRP, have been investigated in cardiovascular patients, tissue mRNA expression was analyzed and correlations to vascular diseases established. Consistent with these findings the generation of cytokine-deficient animals has provided direct evidence for a role of cytokines in atherosclerosis. In vitro cell culture experiments further support the suggestion that cytokines and other innate mechanisms contribute to atherogenesis. Among the initiation pathways of atherogenesis are innate mechanisms, such as toll-like-receptors (TLRs), including the endotoxin receptor TLR4. On the other hand, innate cytokines, such as IL-1 or TNF, or even autoimmune triggers may activate the cells. Cytokines potently activate multiple functions relevant to maintain or spoil homeostasis within the vessel wall. Vasc...Continue Reading

References

Aug 12, 1976·The New England Journal of Medicine·R Ross, J A Glomset
Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E A CarswellB Williamson
Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·X YuG E Sonenshein
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S D CushingA M Fogelman
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J D ZhangS R Sprang
May 30, 1991·Nature·N J Gay, F J Keith
Jun 1, 1991·Immunology Today·G Beck, G S Habicht
Sep 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J M WangA Mantovani
Sep 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·E P AmentoP Libby
Dec 1, 1991·Infection and Immunity·S BhakdiW Fischer
Jan 15, 1990·Biochemical and Biophysical Research Communications·M YoshizumiY Yazaki
May 1, 1988·European Journal of Immunology·T GeigerP C Heinrich
Jun 1, 1989·Journal of Cardiac Surgery·M A Gimbrone
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·T GulickG F Schreiner
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J P PriestleM G Grütter
Sep 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·G K HanssonS Stemme
Sep 1, 1989·Immunology Today·F R Balkwill, F Burke
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A Antonelli-OrlidgeP A D'Amore
Jan 1, 1989·The Journal of Clinical Investigation·D BeasleyN G Levinsky
Apr 25, 1986·Nucleic Acids Research·Y FurutaniS Nakamura
Dec 1, 1986·The Journal of Clinical Investigation·P LibbyC A Dinarello
May 1, 1987·The Journal of Experimental Medicine·S J WarnerP Libby
Jun 1, 1986·The Journal of Clinical Investigation·C A DinarelloR C Reuben

❮ Previous
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Citations

Mar 1, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Xiuru GuanJin Zhou
Apr 14, 2009·Current Atherosclerosis Reports·Athanasios DidangelosManuel Mayr
Dec 29, 2010·International Journal of Inflammation·Markus Schuppler, Martin J Loessner
Jun 26, 2013·Future Medicinal Chemistry·Aimalie L Hardaway, Izabela Podgorski
Mar 11, 2010·Journal of Atherosclerosis and Thrombosis·Waldir G M RelvasFrancisco A H Fonseca
Jan 12, 2013·Cardiovascular Diabetology·Theodor BaarsPetra Kleinbongard
Nov 23, 2011·Lipids in Health and Disease·Mahaya C MatShahrul S Hamid
Jan 19, 2012·Pharmacology & Therapeutics·Anna AstashkinaDavid W Grainger
Apr 27, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Shu-Meng ChengJenn-Haung Lai
Feb 18, 2010·Journal of Cellular and Molecular Medicine·Harald LoppnowKarl Werdan
Jan 5, 2011·Journal of Cellular and Molecular Medicine·Harald LoppnowStefan Rose-John
Nov 13, 2014·Molecular Oral Microbiology·S Amar, M Engelke
Sep 2, 2011·Journal of Autoimmunity·Mary A M RogersKenneth M Langa
Jun 4, 2013·Cytokine·Bas HeinhuisLeo A B Joosten
Jun 26, 2012·International Journal of Cardiology·Daniela PedicinoGiovanna Liuzzo
Feb 2, 2010·Molecular Immunology·Laurel A GrisantiJames E Porter
Oct 15, 2011·The Journal of Thoracic and Cardiovascular Surgery·Christopher W MoehleGorav Ailawadi
Dec 19, 2012·Biochemical and Biophysical Research Communications·Sun-Mi KimKoanhoi Kim
Jan 20, 2011·Annals of Saudi Medicine·Lakhdar GhazouaniTouhami Mahjoub
Dec 27, 2016·Critical Reviews in Clinical Laboratory Sciences·Diana Navas-CarrilloEsteban Orenes-Piñero
Dec 17, 2010·World Journal of Cardiology·Mozow Y Zuidema, Cuihua Zhang
Apr 14, 2018·Cell Biochemistry and Function·Saeede KarbasforushMajid Khaksar
Oct 1, 2011·Circulation Research·Malin C LevinJan Borén
Aug 18, 2010·Periodontology 2000·Sami A ZelkhaSalomon Amar
Jan 27, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Li ChenHarald Loppnow
Aug 13, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Petra KleinbongardGerd Heusch
Jul 25, 2019·Clinical Science·B Sumayyah H Sokeechand, Bernardo L Trigatti
Jun 20, 2012·International Journal of Molecular Medicine·Tebeng Nixon TangiKarin Fransén
May 17, 2019·Indian Journal of Clinical Biochemistry : IJCB·Bobbala IndumathiVijay Kumar Kutala

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