PMID: 3753062Apr 1, 1986Paper

Vascular changes in human leishmaniasis: a light microscope and immunohistological study

Annals of Tropical Medicine and Parasitology
B Veress, A M el Hassan

Abstract

The study of human cutaneous leishmaniasis from Saudi Arabia (37 cases), and of Sudanese mucosal (52 cases) and visceral (27 cases) leishmaniasis revealed the occurrence of vascular alterations. Vasculitis with or without fibrinoid necrosis and fibrin thrombi were found in both the arteries and veins within the area of inflammation in cutaneous and mucosal leishmaniasis; whereas subendothelial oedema, hyalinosis and intimaproliferation were seen in the small arteries of the various organs in visceral leishmaniasis. Immunoperoxidase staining of the cutaneous leishmaniasis lesions showed the presence of IgG and IgA within the endothelial cells, in the media, and in the perivascular space of the diseased vessels. The formation of immune complexes, locally in cutaneous and mucosal leishmaniasis and circulating in visceral leishmaniasis, is considered responsible for these vascular lesions.

References

Dec 14, 1974·Lancet·J D MathewsI R Mackay
Jan 1, 1974·Transactions of the Royal Society of Tropical Medicine and Hygiene·Z K RadwanskiD C Dumonde
May 1, 1974·Atherosclerosis·R N Poston, D F Davies
Jan 1, 1983·The American Journal of Tropical Medicine and Hygiene·E M CarvalhoH Rocha
Jun 1, 1983·The Journal of Infectious Diseases·R D PearsonJ S Davis
Feb 1, 1980·Clinical Pediatrics·E R BlountJ Nernoff
Mar 1, 1980·The American Journal of Tropical Medicine and Hygiene·P DesjeuxA Capron
Jan 1, 1980·Transactions of the Royal Society of Tropical Medicine and Hygiene·D S RidleyA C Barreto
Jan 1, 1959·The Journal of Experimental Medicine·J ROBBINS, C A STETSON

❮ Previous
Next ❯

Citations

May 24, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·A M el-Hassan, E E Zijlstra
Nov 23, 2005·The Journal of Small Animal Practice·E TorrentJ Pastor
Oct 2, 2014·BMC Infectious Diseases·Richard James MaudeMohammad Abul Faiz
Aug 11, 2007·Trends in Immunology·Susanne Nylén, David Sacks

❮ Previous
Next ❯