Vascular cognitive impairment: prodromal stages of ischemic vascular dementia

Dementia and Geriatric Cognitive Disorders
Ciro Ramos-EstébanezJosé Luis Hernández-Hernández

Abstract

To describe the natural history of the prodromal stages of ischemic vascular dementia (pVaD). A sample of 314 inpatients with pVaD or a clini- cal diagnosis of vascular dementia (VaD; lacunar state, Binswanger's disease, pure cortical VaD, corticosubcortical and strategic infarctions) admitted to a teaching tertiary center during a 13-year period was assessed (retrospectively n = 88, prospectively n = 226). Prospective neuropsychological assessment consisted of Mini Mental State Examination, Revised Wechsler Adult Intelligence Scale, Exit-25, Trail Making tests, Blessed Dementia Scale and Camdex H, Global Depression Scale and Hamilton Depression Rating Scale tests. Univariate analysis and logistic regressions are displayed. An unrecognized pVaD was related with a clinical onset with cognitive impairment no dementia (CIND) versus symptomatic cerebrovascular events (p < 0.0001), and with being under therapy with anticoagulant or antiplatelet agents (p < 0.01). Age <85 years at diagnosis of VaD (p < 0.01) correlated with a delayed pVaD diagnosis. CIND onset was associated with a longer prodromal stage (p < 0.01), no clinical strokes during pVaD (p < 0.001), silent ischemia (p < 0.01) and Binswanger's disease (p < 0.01). Vascular c...Continue Reading

Citations

Aug 16, 2012·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S SorbiUNKNOWN EFNS Scientist Panel on Dementia and Cognitive Neurology
Apr 11, 2014·International Psychogeriatrics·Peter EgetoTom A Schweizer
Sep 3, 2010·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·R Scott MackinPatricia A Areán
Jun 15, 2012·Journal of the Neurological Sciences·Silvia BagnoliSandro Sorbi
Jul 25, 2017·Journal of Neurochemistry·Sana Tariq, Philip A Barber
Jun 28, 2014·Molecular Medicine Reports·Shuifen YeJing Cai
Oct 26, 2012·Postgraduate Medicine·Ciro Ramos-EstebanezJose Luis Hernandez
Nov 22, 2014·Postgraduate Medicine·Christopher R Heron, B Brent Simmons

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