"Vascular depression" predicts verbal fluency in older adults

Journal of Clinical and Experimental Neuropsychology
Brian P YochimPeter A Lichtenberg

Abstract

Past research has found links among cerebrovascular risk factors (CVRFs), depression, and cognition in older adults. This study investigated how well baseline cerebrovascular burden and depression predicted verbal fluency three and six months later. Participants were 139 medical rehabilitation patients, age 60 and above. The Geriatric Depression Scale, Charlson Co-Morbidity Index, and Dementia Rating Scale were administered at baseline, and verbal fluency was measured three and six months later. Structural equation modeling found that depression significantly predicted verbal fluency at both time points, independently of demographic variables, baseline cognition, or medical burden. CVRFs correlated with depressive symptoms but did not independently predict verbal fluency. Findings suggest that vascular depression may be a possible signal of impaired brain integrity, consistent with Alexopoulos and colleague's (2000) conceptual framework.

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Citations

Sep 2, 2011·Journal of the International Neuropsychological Society : JINS·Susanne JungwirthPeter Fischer
Oct 22, 2008·Journal of Clinical and Experimental Neuropsychology·Brian P YochimPeter A Lichtenberg
Jul 1, 2014·Journal of Clinical and Experimental Neuropsychology·Matildes F M SobreiroRenerio Fraguas
Jul 24, 2013·International Journal of Geriatric Psychiatry·Jeremy S CarmasinKeith E Whitfield
Oct 24, 2007·Arquivos de neuro-psiquiatria·Maria Teresa Carthery-GoulartRicardo Nitrini

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