Vascular dilation by paeonol--a mechanism study

Vascular Pharmacology
Ya-juan LiKa Bian

Abstract

The goal of this study was to investigate the mechanism underlaying the vasodilatory effect of paeonol, a major active element from the root bark of Chinese herbs Paeonia suffruticosa Andr. and Cynanchum paniculatum (Bunge) Kitagawa. Paeonol relaxed isolated rat aorta rings by 95.6% while the 10(-6) M forskolin-induced vasodilatation used as 100%. The EC(50) of vasodilatation by paeonol is 2.9x10(-4) M. Although paeonol exerted endothelium-independent relaxation, L-NAME treatment inhibited paeonol-induced vasodilation of endothelium intact rings, while indomethacin did not. Both L-NAME and ODQ did not affect paeonol relaxation in the rings without endothelium. In addition, paeonol markedly elevated NO generation in cultured endothelial cells. Pre-treatment of propranolol, glibenclamide, TEA and BaCl(2) did not affect paeonol relaxation of endothelium removed rings. On the other hand, pre-treated of rings (without endothelium) with paeonol markedly blocked vasoconstriction induced by AngII, PGF(2alpha), 5-HT, dopamine, vasopressin, endothelin-1 and PE. The paeonol incubation also significantly attenuated KCl-induced contraction which mainly depended on Ca(2+) influx. In Ca(2+)-free medium (containing 10(-4) M of EGTA and 60 mM o...Continue Reading

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Citations

Oct 15, 2013·The American Journal of Chinese Medicine·Jin-Feng ZhaoTzong-Shyuan Lee
Sep 12, 2015·Phytotherapy Research : PTR·Aida MoohammadareeChainarong Tocharus
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Apr 20, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yean Chun LohMun Fei Yam
Jun 8, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhiqiang WangPeigen Xiao
Dec 21, 2017·The Journal of Pharmacology and Experimental Therapeutics·Ker Woon ChoyMohd Rais Mustafa
Aug 14, 2020·Journal of Oleo Science·Chao-Qi ZhangZheng-Chang Zhong
Dec 14, 2018·Oxidative Medicine and Cellular Longevity·Li LuXiaomei Guo
Sep 29, 2018·Food Science and Biotechnology·Xiao-Miao HanXue-Feng Yang
Aug 1, 2015·Journal of Microencapsulation·Sha-Sha LiQiang Liu
Oct 24, 2019·Mini Reviews in Medicinal Chemistry·Jilei WangJingyong Sun
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shalini VellasamyChoy Ker Woon

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