Abstract
The goal of this study was to investigate the mechanism underlaying the vasodilatory effect of paeonol, a major active element from the root bark of Chinese herbs Paeonia suffruticosa Andr. and Cynanchum paniculatum (Bunge) Kitagawa. Paeonol relaxed isolated rat aorta rings by 95.6% while the 10(-6) M forskolin-induced vasodilatation used as 100%. The EC(50) of vasodilatation by paeonol is 2.9x10(-4) M. Although paeonol exerted endothelium-independent relaxation, L-NAME treatment inhibited paeonol-induced vasodilation of endothelium intact rings, while indomethacin did not. Both L-NAME and ODQ did not affect paeonol relaxation in the rings without endothelium. In addition, paeonol markedly elevated NO generation in cultured endothelial cells. Pre-treatment of propranolol, glibenclamide, TEA and BaCl(2) did not affect paeonol relaxation of endothelium removed rings. On the other hand, pre-treated of rings (without endothelium) with paeonol markedly blocked vasoconstriction induced by AngII, PGF(2alpha), 5-HT, dopamine, vasopressin, endothelin-1 and PE. The paeonol incubation also significantly attenuated KCl-induced contraction which mainly depended on Ca(2+) influx. In Ca(2+)-free medium (containing 10(-4) M of EGTA and 60 mM o...Continue Reading
References
Sep 16, 1992·Biochemical and Biophysical Research Communications·D A PetersonE K Weir
Dec 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K Bian, N Toda
Feb 1, 1993·Circulation Research·I L BuxtonK D Keef
Aug 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·K Bian, K Hermsmeyer
Jun 17, 2003·Methods and Findings in Experimental and Clinical Pharmacology·G-Q ZhangC-H Wu
Jul 3, 2003·Nature Reviews. Molecular Cell Biology·Michael J BerridgeH Llewelyn Roderick
Dec 12, 2003·Biochemical Pharmacology·Xianfeng SunRui Wang
May 17, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Man-Jiang XieHong-Wei Cheng
Aug 23, 2005·Life Sciences·Sai Wang SetoYiu Wa Kwan
Mar 14, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Jun-Hui XueMan-Jiang Xie
Apr 11, 2008·The Journal of Clinical Hypertension·Ka BianFerid Murad
Citations
Dec 4, 2012·International Journal of Molecular Sciences·Jing HuSi-Wang Wang
Nov 28, 2013·PloS One·Sha-Sha LiQiang Liu
Oct 15, 2013·The American Journal of Chinese Medicine·Jin-Feng ZhaoTzong-Shyuan Lee
Sep 12, 2015·Phytotherapy Research : PTR·Aida MoohammadareeChainarong Tocharus
Nov 23, 2011·Phytotherapy Research : PTR·Grace G L YuePing-Chung Leung
Jul 19, 2011·Vascular Pharmacology·Qin LiLianjun Guo
Nov 19, 2014·International Journal of Oncology·Xiuying LiShunlin Xiao
Mar 8, 2011·Brain Research·Jun ZhouStephen C Bondy
Apr 20, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yean Chun LohMun Fei Yam
Nov 10, 2012·PloS One·Hua LiPeng-Cheng Qiu
Aug 7, 2016·Frontiers in Physiology·Lina MaLi Zuo
Jul 28, 2016·Biochemical Pharmacology·Ker-Woon ChoyYu Huang
Jun 8, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhiqiang WangPeigen Xiao
Aug 4, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Ting LiSicen Wang
Mar 30, 2016·Scientific Reports·Hua LiSi-Wang Wang
Dec 21, 2017·The Journal of Pharmacology and Experimental Therapeutics·Ker Woon ChoyMohd Rais Mustafa
Feb 23, 2020·Chronobiology International·Li ZhangJun Chen
Aug 14, 2020·Journal of Oleo Science·Chao-Qi ZhangZheng-Chang Zhong
Nov 18, 2011·Shock·Yu-Ting TsengYi-Ching Lo
Dec 14, 2018·Oxidative Medicine and Cellular Longevity·Li LuXiaomei Guo
Sep 29, 2018·Food Science and Biotechnology·Xiao-Miao HanXue-Feng Yang
Aug 11, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Jing-Xian ChenLan Zheng
Aug 1, 2015·Journal of Microencapsulation·Sha-Sha LiQiang Liu
Aug 22, 2018·Pharmaceutics·Mi Hye KwonHee Eun Kang
Oct 24, 2019·Mini Reviews in Medicinal Chemistry·Jilei WangJingyong Sun
May 31, 2020·Journal of Ethnopharmacology·Xirong ZhouXueyan Fu
Apr 20, 2021·Frontiers in Pharmacology·Fei TangYu-Zhu Tan
Nov 7, 2020·Food & Function·Tingting ZhouFan Yu
Apr 26, 2014·Journal of Natural Products·Grace Gar-Lee YueClara Bik-San Lau
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shalini VellasamyChoy Ker Woon