Vascular disease is associated with facet joint osteoarthritis.

Osteoarthritis and Cartilage
P SuriD J Hunter

Abstract

Epidemiologic studies have demonstrated associations between vascular disease and spinal degeneration. We sought to examine whether vascular disease was associated with lumbar spine facet joint osteoarthritis (FJ OA) in a community-based population. 441 participants from the Framingham Heart Study multi-detector computed tomography (MDCT) Study were included in this ancillary study. We used a quantitative summary measure of abdominal aortic calcification (AAC) from the parent study as a marker for vascular disease. AAC was categorized into tertiles of 'no' (reference), 'low', and 'high' calcification. FJ OA was evaluated on computerised tomography (CT) scans using a four-grade scale. For analytic purposes, FJ OA was dichotomized as moderate FJ OA of at least one joint from L2-S1 vs no moderate FJ OA. We examined the association of AAC and FJ OA using logistic regression before and after adjusting for age, sex and body mass index (BMI). Furthermore, we examined the independent effect of AAC on FJ OA after including the known cardiovascular risk factors; diabetes, hypertension, hypercholesterolemia, and smoking. Low AAC (OR 3.84 [2.33-6.34]; P<or=0.0001) and high AAC (9.84 [5.29-18.3]; <or=0.0001) were strongly associated with FJ...Continue Reading

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Citations

Nov 14, 2012·Nature Reviews. Rheumatology·Alfred C GellhornPradeep Suri
Jul 11, 2014·The Spine Journal : Official Journal of the North American Spine Society·Pradeep SuriJeffrey N Katz
Jan 17, 2013·Nature Reviews. Rheumatology·Ali GuermaziDaichi Hayashi
Jan 15, 2013·Rheumatic Diseases Clinics of North America·Ali GuermaziFrank W Roemer
May 9, 2012·The Spine Journal : Official Journal of the North American Spine Society·Pradeep SuriJeffrey N Katz
Feb 1, 2012·Archives of Physical Medicine and Rehabilitation·Farah HameedPradeep Suri
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Jun 4, 2019·The Journal of Rheumatology·Sultana Monira HussainFlavia M Cicuttini
Aug 21, 2020·Journal of Orthopaedic Surgery and Research·Jun YinZongmiao Wan

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