PMID: 9638515Jan 1, 1997Paper

Vascular dopamine-I receptors and atherosclerosis

Journal of Atherosclerosis and Thrombosis
K YasunariJ Yoshikawa

Abstract

Vascular smooth muscle cell (VSMC) migration and proliferation are believed to play key roles in atherosclerosis. To elucidate the role of vascular dopamine D1-like receptors in atherosclerosis, the effects of dopamine, specific D1-like agonists SKF 38,393, and YM 435 on platelet-derived growth factor (PDGF) BB-mediated VSMC migration, proliferation, and hypertrophy were studied. We observed that cells stimulated by 5 ng/ml PDGF BB showed increased migration, proliferation and hypertrophy. These effects were prevented by coincubation with dopamine, SKF 38,393, or YM 435 at 1-10 mumol/l, and this prevention was reversed by Sch 23,390 (1-10 mumol/l), a specific D1-like antagonist. These actions are mimicked by 1-10 mumol/l forskolin, a direct activator of adenylate cyclase and 8-bromocyclic AMP at 0.1-1 mmol/l. The actions are blocked by a specific protein kinase A (PKA) inhibitor N-[2-(p-bromocinnamylamino) ethyl]-5-isoquinoline-sulfonamide (H 89), but are not blocked by its negative control, N-[2-(N-formyl-p-chlorocinnamylamino) ethyl]-5-isoquinoline sulfonamide (H 85). PDGF-BB (5 ng/ml)-mediated activation of phospholipase D (PLD), protein kinase C (PKC) and mitogen-activated protein kinase (MAPK) activity were significantly s...Continue Reading

References

Mar 1, 1978·The Journal of Physiology·H U BühlerG B Picotti
Feb 11, 1992·Trends in Pharmacological Sciences·D R Sibley, F J Monsma
May 15, 1989·Biochemical and Biophysical Research Communications·T J AbellT Yandle
Nov 1, 1988·The American Journal of Physiology·R A Felder, P A Jose
Jul 18, 1986·Cell·R RossD F Bowen-Pope
Oct 5, 1988·The American Journal of Cardiology·V J Dzau, G H Gibbons
Feb 20, 1986·The New England Journal of Medicine·R Ross
May 1, 1984·The American Journal of Physiology·C R Scheid, F S Fay
Dec 3, 1984·Life Sciences·J C Stoof, J W Kebabian
Jun 1, 1995·The American Journal of Physiology·D P O'ConnellR M Carey
Sep 1, 1995·Circulation Research·S M SchwartzE R O'Brien
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·L M GravesE G Krebs
Nov 12, 1993·Science·S J Cook, F McCormick
Jan 1, 1995·The Journal of Clinical Investigation·P Y YuP A Jose
Jul 1, 1994·Trends in Pharmacological Sciences·P Seeman, H H Van Tol
Oct 1, 1993·The American Journal of Physiology·A KribbenR A Nemenoff
Jan 1, 1993·The American Journal of Physiology·K YasunariT Takeda
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·G PagèsJ Pouysségur
Jan 1, 1993·Annual Review of Neuroscience·J A Gingrich, M G Caron
Jun 1, 1995·Hypertension Research : Official Journal of the Japanese Society of Hypertension·K YasunariT Takeda
Mar 1, 1996·Hypertension·R OzonoR M Carey
May 15, 1996·The Journal of Clinical Investigation·F E AlbrechtP A Jose
Feb 1, 1996·Journal of Hypertension·H KanoJ Yoshikawa
Dec 31, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·K YasunariJ Yoshikawa

❮ Previous
Next ❯

Citations

Dec 7, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Emine M OnalMehmet Kanbay
Feb 10, 2017·Molecular and Cellular Biochemistry·Jun GaoHongzhu Li
Jan 16, 2003·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ling Zhang, Michael S Lidow

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.