PMID: 1201374Oct 1, 1975Paper

Vascular dopamine receptors in the canine hindlimb

British Journal of Pharmacology
C BellR Padanyi

Abstract

1 Increases in femoral blood flow were produced by intra-arterial injections of dopamine (5-50 mug) in some but not all anaesthetized dogs studied, following treatment with the alpha-adrenoceptor antagonist, phentolamine. 2 The dilator effect of dopamine was not due to inhibition of adrenergic vasomotor tone as it was not affected by pharmacological procedures which completely abolished the activity of vastomotor nerves. 3 Blockade of vascular beta-adrenoceptors using propanolol reduced the flow increases produced by dopamine much less than it did those produced by isoprenaline. 4 Responses to dopamine were significantly depressed by intra-arterial administration of ergometrine (0.5 mg). This dose of ergometrine did not reduce femoral dilator responses to acetylcholine, histamine, isopienaline, bradykinin, or 5-hydroxytryptamine. 5 It is concluded that the femoral vascular bed in the dog contains specific vasodilator receptors for dopamine. Ergometrine appears to be a selective antagonist of dopamine at these receptors.

References

Aug 1, 1973·The American Journal of Physiology·C B HigginsS F Vatner
Feb 1, 1968·Comparative Biochemistry and Physiology·R J WalkerG A Kerkut

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Citations

Apr 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·M SchmidtJ L Imbs
Oct 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·R MassinghamS Z Langer
Nov 1, 1982·Pflügers Archiv : European journal of physiology·W Peter, W Riedel
Nov 1, 1978·European Journal of Pharmacology·M Laubie, H Schmitt
Aug 1, 1978·Neuropharmacology·P BevanE Szabadi
Nov 1, 1981·Journal of the Autonomic Nervous System·M Nagai, K Pleschka
Nov 15, 1993·European Journal of Pharmacology·A S HallA J Balmforth
Feb 1, 1977·British Journal of Pharmacology·M G BogaertJ L Willems
Oct 1, 1978·British Journal of Pharmacology·C Bell, A Stubbs
Nov 1, 1979·British Journal of Pharmacology·C Bell, W J Lang

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