Vascular Dynamics Aid a Coupled Neurovascular Network Learn Sparse Independent Features: A Computational Model

Frontiers in Neural Circuits
Ryan T PhilipsV Srinivasa Chakravarthy

Abstract

Cerebral vascular dynamics are generally thought to be controlled by neural activity in a unidirectional fashion. However, both computational modeling and experimental evidence point to the feedback effects of vascular dynamics on neural activity. Vascular feedback in the form of glucose and oxygen controls neuronal ATP, either directly or via the agency of astrocytes, which in turn modulates neural firing. Recently, a detailed model of the neuron-astrocyte-vessel system has shown how vasomotion can modulate neural firing. Similarly, arguing from known cerebrovascular physiology, an approach known as "hemoneural hypothesis" postulates functional modulation of neural activity by vascular feedback. To instantiate this perspective, we present a computational model in which a network of "vascular units" supplies energy to a neural network. The complex dynamics of the vascular network, modeled by a network of oscillators, turns neurons ON and OFF randomly. The informational consequence of such dynamics is explored in the context of an auto-encoder network. In the proposed model, each vascular unit supplies energy to a subset of hidden neurons of an autoencoder network, which constitutes its "projective field." Neurons that receive a...Continue Reading

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Citations

Oct 28, 2017·PLoS Computational Biology·Ryan T PhilipsV Srinivasa Chakravarthy
Mar 13, 2019·Frontiers in Neural Circuits·Vignayanandam Ravindernath MuddapuSrikanth Ramaswamy
Jul 3, 2021·Frontiers in Computational Neuroscience·Bhadra S KumarS Pushpavanam

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Methods Mentioned

BETA
feature extraction

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