Vascular effects and antioxidant activity of two Combretum species from Democratic Republic of Congo

Journal of Ethnopharmacology
Francine Nsuadi MangaStéphanie Pochet

Abstract

Combretum racemosum P. Beauv (Combretaceae) leaves (CrLv) and root bark (CrRB) and Combretum celastroides subsp. laxiflorum Welw (Combretaceae) leaves (ClLv) are used in Congolese traditional medicine for several therapeutic purposes, notably for the treatment of conditions consistent with hypertension. The present study aims to investigate the vasorelaxant and in vitro antioxidant activities of these plants polar extracts and to examine the in vivo antihypertensive effect of the extract which displays the most potent vasorelaxant effect. The vasorelaxant effect of CrLv, CrRB and ClLv methanolic extracts was studied on rat aorta rings pre-contracted with phenylephrine (PE, 1 μM) in the presence or absence of the endothelium. In some experiments, prior to the addition of the extract, rings were incubated for 30 min with either L-N(G)-nitroarginine methyl ester (L-NAME; 100 μM), a nitric oxide synthase (NOS) inhibitor, indomethacin (10 μM), a cyclooxygenase inhibitor, or 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ; 10 μM), a guanylate cyclase inhibitor. The antioxidant activity was determined by the measurement of the scavenging ability of extracts towards the stable free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH). Blood p...Continue Reading

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Citations

Jan 6, 2016·Life Sciences·Maryam RameshradRohollah Fadaei Fouladi
Feb 16, 2013·Journal of Ethnopharmacology·Francine Nsuadi MangaStéphanie Pochet
Mar 8, 2016·Fitoterapia·Diane Patricia Apie GossanLaurence Voutquenne-Nazabadioko
Feb 6, 2013·International Immunopharmacology·Igor A SchepetkinMark T Quinn
Apr 20, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yean Chun LohMun Fei Yam

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