Vascular effects in dogs of pinacidil (P 1134), a novel vasoactive antihypertensive agent

European Journal of Pharmacology
U B Olsen, E Arrigoni-Martelli

Abstract

In pentobarbital sodium-anaesthetized dogs, pinacidil was infused for approximately 5 min into the carotid, coronary, femoral or renal artery at a rate of 10 micrograms/kg per min. The infusion, which did not affect systemic blood pressure, rapidly and markedly increased blood flow to any of the regions studied. When given i.v., 0.2 mg/kg pinacidil caused a moderate reduction in mean arterial blood pressure (15-20 mmHg) associated with an increase in coronary and renal blood flow while femoral and carotid blood flow remained unchanged; 0.5 mg/kg led to a marked (40-60 mmHg) reduction in blood pressure associated with an increase in coronary blood flow whereas renal, carotid and femoral blood flow stabilized at control levels. Indomethacin (2.5 mg/kg i.v.) failed to reverse the hypotension induced by pinacidil. The results are in accord with the concept that the vascular effect of pinacidil is due to direct smooth muscle relaxation which does not depend on prostaglandin synthesis.

References

Aug 1, 1978·Journal of Medicinal Chemistry·H J PetersenE Arrigoni-Martelli
Mar 15, 1968·Experientia·J KapitolaI Jahoda

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Citations

Jan 1, 1993·European Journal of Clinical Pharmacology·P GirardJ P Boissel
Jan 1, 1985·European Journal of Clinical Pharmacology·E G BreenJ A Keogh
Jan 1, 1989·European Journal of Clinical Pharmacology·J L SaumetJ P Boissel
Nov 22, 1988·European Journal of Pharmacology·J E Nielsen-KudskC B Nielsen
Jan 1, 1990·Pharmacology & Therapeutics·G Edwards, A H Weston
Jan 1, 1989·Pharmacology & Toxicology·C B NielsenF Nielsen-Kudsk
Jan 1, 1988·Clinical and Experimental Hypertension. Part A, Theory and Practice·M P Cinquegrani, C S Liang
Apr 21, 2010·Experimental Biology and Medicine·Gregory M Dick, Johnathan D Tune
Jan 1, 1985·The Journal of International Medical Research·M S Laher, M P Hickey
Sep 1, 1986·British Journal of Clinical Pharmacology·D P NichollsR G Shanks
Jul 1, 1987·Journal of Clinical Pharmacology·M C Rijk, T Thien

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