Vascular effects of oxysterols and oxyphytosterols in apoE -/- mice

Atherosclerosis
Oliver WeingärtnerUlrich Laufs

Abstract

The aim of our study was to investigate vascular effects of oxysterols and oxyphytosterols on reactive oxygen species (ROS), endothelial progenitor cells, endothelial function and atherogenesis. Male apoE-/-mice were treated with cholesterol, sitosterol, 7-ß-OH-cholesterol, 7-ß-OH-sitosterol, or cyclodextrin by daily intraperitoneal application. The respective concentrations in the plasma and in the arterial wall were determined by gas chromatography-flame ionization or mass spectrometry. ROS production was assessed by electron-spin resonance spectroscopy in the aorta, endothelial function of aortic rings and atherosclerosis in the aortic sinus was quantitated after 4 weeks. Compared to vehicle, there was no difference in plasma cholesterol levels and arterial wall concentrations after i.p. application of cholesterol. 7-ß-OH-cholesterol concentrations were increased in the plasma (33.7±31.5 vs. 574.57.2±244.92 ng/ml) but not in the arterial wall (60.1±60.1 vs. 59.3±18.2 ng/mg). Sitosterol (3.39±0.96 vs. 8.16±4.11 mg/dL; 0.08±0.04 vs. 0.16±0.07 μg/mg, respectively) and 7-ß-OH-sitosterol concentrations (405.1±151.8 vs. 7497±3223 ng/ml; 0.24±0.13 vs. 16.82±11.58 ng/mg, respectively) increased in the plasma and in the aorta. The i....Continue Reading

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Citations

Feb 28, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Blanca BarriusoIciar Astiasarán
Mar 5, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Sabine BaumgartnerJogchum Plat
May 2, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Hans-Frieder SchöttDieter Lütjohann
Aug 26, 2016·Journal of Food Science·Magdalena BrzeskaArkadiusz Szterk
Nov 5, 2016·European Journal of Lipid Science and Technology : EJLST·Yuguang LinElke A Trautwein
Apr 4, 2017·Journal of Vascular Research·Marie-Ann EwartSimon Kennedy
May 11, 2018·Lipids·Yvonne OligschlaegerRonit Shiri-Sverdlov
Oct 4, 2017·Lipids in Health and Disease·Adam Zmysłowski, Arkadiusz Szterk
Dec 30, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Shana R WatsonSusan M Lessner
Jan 6, 2021·Critical Reviews in Food Science and Nutrition·Fan JieBaiyi Lu
Sep 30, 2021·Journal of Agricultural and Food Chemistry·Mengmeng WangBaiyi Lu

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