Vascular elastic fiber heterogeneity in health and disease.

Current Opinion in Hematology
Carmen M Halabi, Beth A Kozel

Abstract

Elastin has historically been described as an amorphous protein that functions to provide recoil to tissues that stretch. However, evidence is growing that elastin's role may not be limited to biomechanics. In this minireview, we will summarize current knowledge regarding vascular elastic fibers, focusing on structural differences along the arterial tree and how those differences may influence the behavior of affiliated cells. Regional heterogeneity, including differences in elastic lamellar number, density and cell developmental origin, plays an important role in vessel health and function. These differences impact cell-cell communication, proliferation and movement. Perturbations of normal cell-matrix interactions are correlated with human diseases including aneurysm, atherosclerosis and hypertension. Although classically described as a structural protein, recent data suggest that differences in elastin deposition along the arterial tree have important effects on heterotypic cell interactions and human disease.

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Citations

Apr 12, 2021·Mechanisms of Ageing and Development·Soo Hyuk KimMingyi Wang
Jun 16, 2021·Molecular Biology Reports·María M Adeva-AndanyRaquel Funcasta-Calderón
Jul 6, 2021·Frontiers in Cell and Developmental Biology·Francesco VasuriGianandrea Pasquinelli

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