Vascular Endothelial Dysfunction during Cardiac Surgery: On-Pump versus Off-Pump Coronary Surgery.

European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
Florian BrettnerDirk Bruegger

Abstract

Cardiac surgery often causes ischemia and development of a systemic inflammatory response syndrome, which impairs vascular barrier function, normally maintained by the endothelial cell line and the endothelial glycocalyx (EG). The EG normally covers and protects healthy endothelial cells throughout the vasculature. The aim of the present study was to assess the disruption of the cellular part of the microvascular barrier by determining parameters of endothelial cell activation known to influence and reflect cell-cell junctional integrity. Particular attention was placed on angiopoietins and their important effects on endothelial gap junctions. Furthermore, comparative measurements were undertaken in patients undergoing on- and off-pump cardiac surgery, the latter group presumably experiencing less ischemic stress. 30 patients undergoing elective coronary artery bypass surgery were assigned to the conventional coronary artery bypass (CCAB) group (n = 15) or the off-pump coronary artery bypass grafting (OPCAB) group (n = 15). Blood samples were obtained for measuring angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), vascular endothelial (VE)-cadherin, and endocan at various time points. There were significant increases in all measu...Continue Reading

References

Aug 23, 1996·The Journal of Biological Chemistry·P LassalleA B Tonnel
Jan 1, 1997·The Annals of Thoracic Surgery·E M BoyleE D Verrier
Mar 31, 2000·Nature Medicine·G ThurstonG D Yancopoulos
Sep 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D BéchardP Lassalle
Jun 24, 2004·Best Practice & Research. Clinical Anaesthesiology·Jan Larmann, Gregor Theilmeier
May 5, 2005·The Journal of Pharmacology and Experimental Therapeutics·Fiorentina RoviezzoAndreas Papapetropoulos
Jan 21, 2006·Critical Care Medicine·Arnaud ScherpereelPhilippe Lassalle
Sep 7, 2007·Journal of Cardiac Surgery·Shahzad G Raja, Geoffrey A Berg
Dec 29, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Dietmar Vestweber
Jul 31, 2008·Critical Care : the Official Journal of the Critical Care Forum·Alexander LukaszPhilipp Kümpers
Nov 26, 2008·Critical Care : the Official Journal of the Critical Care Forum·Philipp KümpersJan T Kielstein
Aug 8, 2009·The Journal of Thoracic and Cardiovascular Surgery·Dirk BrueggerFrank Christ
Oct 12, 2010·The Journal of International Medical Research·R-Y ZhangY-Q Tang
Oct 1, 2011·Journal of Critical Care·Mark E MikkelsenJason D Christie
Mar 8, 2012·Current Opinion in Hematology·Elisabetta Dejana, Costanza Giampietro
Mar 19, 2013·Experimental Cell Research·Lauri Eklund, Pipsa Saharinen
Apr 29, 2014·Microvascular Research·Dunja M MihajlovicTatjana N Cebovic
May 16, 2015·Cardiovascular Research·Sven FlemmingNicolas Schlegel
Mar 10, 2016·Critical Care : the Official Journal of the Critical Care Forum·Tobias HilbertMarkus Velten

❮ Previous
Next ❯

Citations

Oct 28, 2018·Critical Care : the Official Journal of the Critical Care Forum·Nathalie De Freitas CairesPhilippe Lassalle
Sep 19, 2019·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Thomas SallerJohannes Ehler
Jul 14, 2020·Journal of Biochemical and Molecular Toxicology·Huan-Qiu LiuHai-Chun Ma

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.