Vascular endothelial growth factor-A and Poly(A) binding protein-interacting protein 2 expression in human head and neck carcinomas: correlation and prognostic significance.

British Journal of Cancer
C OnestoG Pagès

Abstract

Vascular endothelial growth factor-A (VEGF-A) has been demonstrated to play an important role in tumour angiogenesis and to influence prognosis in many cancers. However its prognostic value in head and neck squamous cell carcinomas (HNSCCs) remains controversial. Therefore, we investigated the clinical relevance of VEGF-A expression in HNSCCs and analysed whether its expression was associated with PAIP2 protein levels, a VEGF-A mRNA-binding partner that strongly regulates VEGF-A expression in tissue culture. We determined the correlation of VEGF-A and PAIP2 protein levels, quantitatively evaluated in tumour tissue homogenates from 54 patients with HNSCC, to clinicopathological parameters. We showed that VEGF-A expression in HNSCC is correlated to the stage of tumour differentiation (P=0.050) and is an independent prognostic factor for progression-free survival (P=0.001) and overall survival (P=0.0004). In a pharynx carcinoma cell line, we demonstrated by RNA interference that VEGF-A expression is closely controlled by PAIP2. Moreover, in human HNSCCs, VEGF-A expression is significantly correlated to PAIP2 protein levels (P=0.0018). Nevertheless, PAIP2 expression is associated with neither clinicopathological factors nor patient...Continue Reading

References

Nov 28, 1997·American Journal of Surgery·R J EismaD L Kreutzer
Apr 16, 1998·The Journal of Biological Chemistry·N S LevyA P Levy
May 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B D SmithB G Haffty
Apr 28, 2001·Neoplasia : an International Journal for Oncology Research·O GalloE Masini
Nov 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Harold F Dvorak
Jan 8, 2003·Seminars in Oncology·Judah Folkman
Apr 20, 2004·Cancer Cell·Li MaoVassiliki A Papadimitrakopoulou
Apr 29, 2004·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Ronald SchimmingRainer Schmelzeisen
May 7, 2004·The New England Journal of Medicine·Jacques BernierUNKNOWN European Organization for Research and Treatment of Cancer Trial 22931
Jun 4, 2004·The Journal of Biological Chemistry·Cercina OnestoGilles Pagès
Aug 4, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Shigeru KimuraKazuaki Chayama
Aug 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Carsten DenkertSteffen Hauptmann
Oct 12, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Panayiotis A KyzasNiki J Agnantis
Dec 16, 2004·Seminars in Oncology·Ezra E W Cohen
Feb 3, 2005·Nature Reviews. Cancer·Keith D HunterPaul R Harrison
Mar 5, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Panayiotis A KyzasJohn P A Ioannidis
Mar 24, 2005·Cancer Metastasis Reviews·Susanne J RogersSuzanne A Eccles

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Citations

Apr 5, 2014·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Paola Griseri, Gilles Pagès
Jun 19, 2007·Antioxidants & Redox Signaling·Eui Jung MoonMark W Dewhirst
Feb 5, 2008·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Chiara BianchiniRoberta Piva
Oct 3, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Jieli Chen, Michael Chopp
Mar 7, 2007·Expert Review of Anticancer Therapy·John G Devlin, Corey J Langer
Jan 19, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David S YooDavid M Brizel

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Methods Mentioned

BETA
ELISA
transfection
xenografts

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R

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