Vascular endothelial growth factor and carotid intima-media thickness in patients with Behçet's disease.

Clinical Rheumatology
Mehmet Akif OztürkA Mesut Onat

Abstract

There is morphologic evidence of subclinical atherosclerosis in Behçet's disease (BD) patients obtained by high-resolution B-mode ultrasonography (US). Vascular endothelial growth factor (VEGF) is a potent angiogenetic factor and a marker for endothelial dysfunction. VEGF could contribute to the pathological events in BD. VEGF could also be an important factor in the progression of atherosclerosis. In this study, we investigated whether there is correlation between intima-media thickness (IMT) of the carotid arteries and serum VEGF levels in BD patients and healthy controls. Twenty-one patients with BD (male/female: 15/6, mean age: 35.8 +/- 8.6 years) were individually matched to control subjects on the basis of age (within 3 years) and sex. Carotid IMT of the subjects was measured by high-resolution B-mode US. Mean IMT values of common carotid arteries were 0.86 +/- 0.18 mm for patients with BD, and 0.57 +/- 0.14 mm for healthy controls (p < 0.001). Mean VEGF levels were 130.41 +/- 58.28 pg/ml for patients with BD and 82.69 +/- 25.03 pg/ml for healthy controls (p < 0.001). There was no correlation between VEGF levels in the control group and in the BD group, but there was a significant correlation between VEGF levels and mean ...Continue Reading

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Citations

May 19, 2010·Biomarkers in Medicine·Alexander TorresCharles J Malemud
Aug 5, 2015·Seminars in Arthritis and Rheumatism·Mira MerashliPaul Richard Julian Ames
Dec 5, 2013·Angiology·Sevket BaltaMustafa Demir
Jul 18, 2018·Scandinavian Journal of Clinical and Laboratory Investigation·Erdim SertogluTaner Ozgurtas
Oct 30, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·I BaltaM Eksioglu
Jul 3, 2015·International Journal of Dermatology·Mohammad Shahidi-DadrasOmid Zargari
Apr 30, 2016·Oral Diseases·Murat SereflicanBetul Kizildag
Aug 3, 2017·Korean Circulation Journal·Sikarin UpalaAnawin Sanguankeo

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