PMID: 11314944Apr 21, 2001Paper

Vascular endothelial growth factor and soft tissue sarcomas: tumor expression correlates with grade

Annals of Surgical Oncology
C ChaoB Eisenberg

Abstract

Vascular endothelial growth factor (VEGF), an endothelial-specific mitogen overexpressed in various epithelial malignancies is thought to be a potent regulator of angiogenesis. We hypothesized that some soft tissue sarcomas, due to their high propensity for hematogenous metastases (1) would overexpress VEGF, (2) that the degree of expression may represent a significant biologic predictor for disease-specific survival, and (3) that recurrent tumor would express as high or higher VEGF compared with the primary tumor. Selected paraffin-embedded tissue of surgical specimens from 79 patients with soft tissue sarcomas, treated between 1989 and 1995 were stained with a rabbit polyclonal anti-VEGF antibody at a concentration of 2 microg/ml. Slides were assessed for VEGF expression as high or low by two investigators blinded to the clinicopathologic data. Twelve patients had VEGF expression of their primary tumors, and their recurrent tumors were compared. The Fishers' exact test assessed for differences in VEGF expression; survival analyses were performed according to the methods of Kaplan and Meier. Seventy-eight percent (29 of 37) of patients who died of disease had high VEGF expression. However, VEGF expression was not an independen...Continue Reading

References

Jan 3, 1991·The New England Journal of Medicine·N WeidnerJ Folkman
Apr 3, 1998·Annals of Surgical Oncology·N C SaenzM F Brennan
Jul 17, 1998·The American Journal of Pathology·P SalvenH Joensuu
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·C K GoldmanD T Curiel
Dec 22, 1998·Journal of Cancer Research and Clinical Oncology·G WangT Liu
Feb 25, 1999·Annals of Surgical Oncology·L T NeitzelM P Malafa
Sep 4, 1999·Journal of Cancer Research and Clinical Oncology·U GraevenW Schmiegel

❮ Previous
Next ❯

Citations

Aug 6, 2008·Clinical & Experimental Metastasis·Junji WasaNaoki Ishiguro
Oct 1, 1992·Clinical Radiology·E MoskovicJ M Thomas
Aug 15, 2003·Surgical Oncology Clinics of North America·Rosa F Hwang, Kelly K Hunt
Jul 13, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C F VerschraegenT Bocklage
Jun 16, 2012·Sarcoma·Juan Martín LiberalOscar M Tirado
Nov 1, 2011·Drugs·Sujana Movva, Claire Verschraegen
Aug 20, 2014·South Asian Journal of Cancer·Thin Thin WinYusri Yusuf
Sep 18, 2013·Critical Reviews in Oncology/hematology·Girolamo RanieriGiovambattista De Sarro
Jan 15, 2016·Veterinary and Comparative Oncology·N HoltermannJ Hirschberger
May 12, 2010·Critical Reviews in Oncology/hematology·Fabio A B SchutzCora N Sternberg
Jun 3, 2008·The Surgical Clinics of North America·Katherine Thornton
Sep 1, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F DuffaudW T van der Graaf
Dec 25, 2008·International Journal of Cancer. Journal International Du Cancer·Yoshinao OdaMasazumi Tsuneyoshi
Dec 21, 2012·Pediatric Blood & Cancer·Douglas S HawkinsUNKNOWN COG Soft Tissue Sarcoma Committee
Jan 7, 2010·Cancer·Kristen Ganjoo, Charlotte Jacobs
Sep 29, 2004·Cytokine & Growth Factor Reviews·Keping XieSuyun Huang
Jul 11, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Michael KreuterRolf M Mesters
Oct 22, 2014·Journal of Surgical Oncology·Douglas Sborov, James L Chen
Mar 13, 2014·Critical Reviews in Oncology/hematology·Yvonne M H Versleijen-JonkersWinette T A van der Graaf
Jul 16, 2016·Developmental Cognitive Neuroscience·Laura Chaddock-HeymanArthur F Kramer
Feb 15, 2013·Expert Review of Anticancer Therapy·Anastasia ConstantinidouRobin L Jones
Nov 26, 2013·Expert Opinion on Pharmacotherapy·Juan Martin-LiberalIan Judson
Feb 1, 2017·Expert Review of Clinical Pharmacology·Maristella SaponaraAlessandro Gronchi
Jan 7, 2018·BMC Cancer·Virginia Di PaoloAngela Di Giannatale
Nov 7, 2008·The Oncologist·Stefan SleijferJean-Yves Blay
Jan 23, 2008·Expert Opinion on Therapeutic Targets·Olivia Aranha, Mark Agulnik
Aug 16, 2013·Expert Review of Anticancer Therapy·Juan Martin-LiberalCharlotte Benson
Mar 16, 2013·Expert Opinion on Pharmacotherapy·Jaap Verweij, Stefan Sleijfer
Aug 21, 2015·Expert Opinion on Investigational Drugs·Nisha Mohindra, Mark Agulnik

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinosarcoma

Carcinosarcoma is a malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. Discover the latest research on carcinosarcoma here.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Related Papers

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
C C WestM W R Reed
Virchows Archiv : an International Journal of Pathology
Ken ShintaniAtsumasa Uchida
© 2021 Meta ULC. All rights reserved